Join/Watch the weekly
TMAU UP Podcasts

MEBO Private Facebook Group
to join : contact
maria.delatorre@meboresearch.org

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact map@meboresearch.org

MEBO TMAU urine test

MEBO Research
TMAU Urine Test
United States only
PROGRAM IS PERMANENTLY SUSPENDED AS OF 2 MAY 2017

Click here for
REQUISITION FORM
Incomplete applications
will NOT be processed

SEE UPDATES HERE

1
test
$150 plus
shipping costs
2
tests
$250 plus
shipping costs

TWO PAYMENT PLAN OPTION
Send email to maria.delatorre@meboresearch.org to arrange, AFTER filling out Requisition Form, please.

Test analysis performed in batches of 20 or more

DATE: 2 MAY 2017
Currently on : PROGRAM IS TEMPORARILY SUSPENDED

Samples analyzed since June 2012 :
352
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
BannerFans.com
RESEARCH DETAILS

DONATIONS THRU 31-NOV-2016:
£ 943.03/GBP
$ 568.00/USD

TOTAL at today's ROE
£0.80/GBP = $1.00/USD

£1,398.07 = $1,745.14

MEBO UK PAYPAL FOR TRINZYME

********
MEBO US PAYPAL FOR TRINZYME

Your currency will be automatically converted to USD or GBP by PayPal.

Option: pay with your credit card instead of PayPal account by clicking on either Donate button above.

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed

Subscribe to Blog

Enter your email address:

Delivered by FeedBurner

You will be sent a verification email

Subscribe in a reader

Blog Archive

Wednesday, January 7, 2009

Secondary Trimethylaminuria explained

Keywords/concepts:
Primary Trimethylaminuria urine test (TMAU1)
Secondary Triethylaminuria urine test (TMAU2)
Trimethylamine-N-Oxide
Trimethylamine
Overgrowth of bacteria that produce trimethylamine
DNA test looks for known FMO3 mutants/polymorphisms. FMO3 DNA test.


Primary Trimethylaminuria urine test with Gas Chromatography/Mass Spectrometry : This is a test of trimethylamine-n-oxide and trimethylamine levels after a (presumed) trimethylamine load of some sort (either choline or foods containing choline, relying on the gut bacteria to turn it into trimethylamine). FMO3 enzyme turns trimethylamine into non-odorous trimethylamine-n-oxide. In a normal person, about 91% or more of the TMA is expected to be oxidized to TMA-Oxide by FMO3 in the liver. There is no internationally agreed level at which abnormal levels are categorized, but as a guideline, one expert suggests :

TMAO x 100/TMA + TMAO = more than 90%
TMAO x 100/TMA + TMAO = 70% - 90% : implies 'mild' TMAU
TMAO x 100/TMA + TMAO = less than 70% : suggests 'severe' TMAU

Secondary Trimethylaminuria urine test with Gas Chromatography/Mass Spectrometry : It seems secondary TMAU (TMAU2) is supposed to be all forms of increased TMA levels not to do with a genetic FMO3 deficiency, but in practice seems to be used to  label people with excessive TMA and TMAO levels who are also converting over 90% of the TMA to TMA-oxide. It usually implies they have an overgrowth of TMA-producing bacteria. If over 90 % conversion is reached, they seem to have a normal functioning FMO3 enzyme, but are producing so much TMA that the TMA and TMAO levels are very high and there is still enough TMA unconverted to produce a smell. This is to do with TMA concentration. Most labs do not seem to take TMAU2 into consideration in their results, with Sheffield Children's Hospital being an exception. Their current acceptable level of TMA is set at under 10.8. People can have both TMAU1 and TMAU2 (i.e. genetic TMAU and TMA overgrowth). Someone with only TMAU2 due to bacterial overgrowth should in theory be totally curable (by eradicating the bacteria overgrowth)  

Example of TMAU2 result :
TMA 20
TMAO 380
% conversion :  95% (normal)
TMA is over 10.8 (Sheffield level) so TMA smell still expected

Someone with only Secondary Trimethylaminuria would likely be advised not to do the DNA test, but at this point in understanding the problem a suggestion is to do the DNA test if possible if in doubt.

More information on TMAU testing

0 comments:

Post a Comment