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Sunday, May 22, 2011

23andme.com DNA test not as thorough for FMO3 testing as hoped

In a previous post it was suggested that the 23andme.com DNA test may be a good way of DNA testing for FMO3 variants/mutants inexpensively. However, it seems that the number of FMO3 SNPs checked for is not as comprehensive as hoped. It checks for 56 FMO3 SNPs in total. Of those, only 17 are at codons with known variants/mutants. Most of the others seem to be to do with FMO3 introns (introns will be discussed in a later post) and about 5 are currently unlisted for any information.

It tests for 17 variants/mutants, out of about 50 known variants/mutants. Most of the 17 are common polymorphisms/variants, but the rarer more severe mutants are not checked for.

The variants, mutants tested for are at the codons listed below (an FMO3 protein is made up of 532 codons)

82, 147, 158 ,205
,239 ,257 ,277 ,285
,302 ,305 ,308 ,360
,362 ,486 ,502 ,503 ,510

This does not include the codons known to have rarer known variants/mutants (about 300 ?) such as at codon :

32, 37, 51, 52, 58, 61, 64,
66, 114, 143, 148, 153, 187
197, 198, 199, 201, 223, 237,
238, 314, 387, 388, 394, 415
434, 470, 475, 492, 500

So it looks like the 23andme.com genetic testing service is currently not suitable for FMO3 DNA testing other than for the more common FMO3 variants. It should be also kept in mind that much more is still to be learnt about FMO3 genetics, and even a comprehensive test is currently still capable of a 'false negative' result. For example, little is known of the FMO3 introns (all the testing and research mostly involving the exons), as explained in this post

23andme do update their SNP testing chip occasionally, so in future it is possible it will be more thorough for FMO3. But FMO3 seems a low priority to them so it is unlikely, and if you have already used their service you would need to retest


pubmed list of FMO3 SNP's

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