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Tuesday, October 8, 2013

Odorous chemicals produced in the gut

There is some confusion about whether fecal matter is flowing in the bloodstream to produce body or breath odor conditions; it is not. It is common knowledge that if fecal matter, with all its millions of microbes, enters the bloodstream, it could potentially cause sepsis and possibly be fatal. That's why doctors rush a patient to surgery when there's a ruptured diverticulum or when the appendix ruptures. Of course, these cases are usually accompanied by infection, but if the microbes in feces enters the bloodstream, one would be in serious life-threatening problem.

odorous chemicals are produced by gut microbes when the microbes take up the food we eat, release odorous chemicals, that then pass through to the bloodstream.
After listening to the webinar series hosted by RareConnect, and in particular Dr. Danielle Reid's presentation, which addresses gut microbial production of trimethylamine (TMA) and the expert interviews in this blog and other sites, and reading articles on TMAU and other body/breath odor conditions, one can determine that the odorous chemicals are produced by gut microbes when the microbes take up the food we eat, release odorous chemicals, that then pass through to the bloodstream. This is what causes systemic body and/or breath odor. Body odor can also occur in persons who have a fully functional FMO3 or other metabolic enzymes, when faced with an overproduction of odorous chemicals by gut microbes, as in the case of (but not limited to) Secondary TMAU. Nonetheless, in cases of FMO3 or other metabolic enzyme deficiencies, the metabolic enzymes cannot catalyze the chemical reactions to change the odorous chemicals into its non-odorous state, so the odor will become that much more intense.

An EXAMPLE would be in the case of TMAU, and there are other metabolic processes involving other odorous chemicals. If one's gut bacteria produces a very high level of the very odorous chemical, trimethylamine (TMA), and the FMO3 metabolic enzyme can handle the load, then the metabolic enzyme cannot add an oxygen molecule to the odorous chemical to convert it to a non-odorous chemical, trimethyl-N-Oxide (TMAO). So free odorous TMA remains in the bloodstream and the body's cleansing organs (kidneys, lungs, skin) try to expel it from the body. When it leaves the body, that's when others can smell it.

This is why bathing is only a temporary, though much needed, solution, and special soaps, shampoos, and cleansers are needed. The body will continue to keep trying to expel free TMA, or any other odorous chemicals that have not been metabolized into non odorous chemical(s), until the blood it clean of it (them).

HOW TO CONTROL ODOR?


This is why so much focus in the various protocols is directed at the gut. A very strong focus is given to diet. Basically, the goal is to not feed the microbes with the foods they use to create odorous chemicals. Charcoal adsorbs chemicals in the gut and excretes them in feces, so they won't pass to the bloodstream. And this is why attention is given to help the cleansing organs expel odorous chemicals by drinking plenty of water, so that the kidneys can wash away the chemicals. Doing cardiovascular exercise is extremely helpful in helping the lungs breath out the chemicals it picks up in the alveoli when the heart is pumping faster and blood-flow moves quickly through the alveoli, where gas exchange takes place in the capillaries. Cardiovascular exercise helps remove the chemicals in perspiration and oil glands. This is then washed away with bathing. This cleansing process takes as long as it takes to finally remove as much odorous chemicals from the body that normal human olfactory systems detect. If the diet is done correctly and new odorous chemicals are not produced in excess, so the metabolic enzymes are able to convert them to non-odorous chemicals.

At this time, there is research taking place for a therapeutic (medicine), "A therapy for body and breath malodour disorder Trimethylaminuria (TMAU)". This is taking place at the University College of London by Principal Investigator, Dr. Elizabeth Shephard, with the £358,000 GBP (an equivalent to about a half million dollars) awarded by the UK Medical Research Council (MRC). The Trinzyme Project was created as a fundraising tool to help with this research so that the therapeutic will be at a low cost to all sufferers around the world.

We as a community of sufferers, do hope that this therapeutic will change the whole odor-management protocol as we know it today, so that sufferers can have greater control over their odor conditions and thus lead more normal lives.

María


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