Join/Watch the weekly
TMAU UP Podcasts

MEBO Private Facebook Group
to join : contact
maria.delatorre@meboresearch.org

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact map@meboresearch.org

MEBO TMAU urine test

MEBO Research
TMAU Urine Test
United States only
PROGRAM IS PERMANENTLY SUSPENDED AS OF 2 MAY 2017

Click here for
REQUISITION FORM
Incomplete applications
will NOT be processed

SEE UPDATES HERE

1
test
$150 plus
shipping costs
2
tests
$250 plus
shipping costs

TWO PAYMENT PLAN OPTION
Send email to maria.delatorre@meboresearch.org to arrange, AFTER filling out Requisition Form, please.

Test analysis performed in batches of 20 or more

DATE: 2 MAY 2017
Currently on : PROGRAM IS TEMPORARILY SUSPENDED

Samples analyzed since June 2012 :
352
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
BannerFans.com
RESEARCH DETAILS

DONATIONS THRU 31-NOV-2016:
£ 943.03/GBP
$ 568.00/USD

TOTAL at today's ROE
£0.80/GBP = $1.00/USD

£1,398.07 = $1,745.14

MEBO UK PAYPAL FOR TRINZYME

********
MEBO US PAYPAL FOR TRINZYME

Your currency will be automatically converted to USD or GBP by PayPal.

Option: pay with your credit card instead of PayPal account by clicking on either Donate button above.

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed

Subscribe to Blog

Enter your email address:

Delivered by FeedBurner

You will be sent a verification email

Subscribe in a reader

Blog Archive

Monday, March 9, 2015

IGEM 2014 competition : French graduates produce enzyme that neutralizes trimethylamine

tmau research
Click for project link
French graduates based at a Paris University genetically engineered a skin bacteria to make it rich in an enzyme (trimethylamine mono-oxygenase) that oxidizes (neutralizes) trimethylamine to TMA-oxide. The experiment was for an annual international genetic engineering contest for undergraduate teams (IGEM 2014) and was proven to work in a lab (i.e. the concept of proven 'in a test tube').

Link : Something Fishy (IGEM 2014)

The undergraduate team are based at
Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal,
South wing, 2nd floor
Paris Descartes University

The team seem to be called 'Paris Bettencourt' for the annual competition. Perhaps most of their funding is by the Bettencourt Foundation (Bettencourt being the founding family of L'oreal brand).

The experiment :
The experiment to oxidize trimethylamine was one of 4 projects they did in relation to body odor and genetic engineering. In this project, they took a TMA oxidizing enzyme (trimethylamine mono-oxygenase) from a non-human bacteria (Ruegeria pomeroyi) and put it in  E.coli and Corynebacterium striatum, a skin-native bacterium.

Results :
It seems that they were able to put the TMA oxidizing enzyme into E Coli and the Corynebacterium striatum which is a skin-native bacterium 

They put the genetically modified TMM rich E Coli in a TMA liquid and it did oxidize much of the TMA to TMAO.

Possible applications :
They mention the possibility of a TMM-rich bacteria added to a spray or cream to put on the skin and eliminate TMA on the skin.

Presumably another possibility is to make a GM  skin-native bacteria rich in TMM enzyme that could be nurtured to live on humans (?)

Possibly an internal therapy answer could be formulated , such as a TMM rich probiotic.

Final comment :
The big question is whether these types of answers are only possible now or could have been found earlier but have not due to no interest in TMAU/FMO3 by the research community overall. It is also not known if the above project is being followed up on. 

The project says TMM is not just TMA specific, so perhaps it will work on other/all smelly substrates which may be the same as FMO3 substrates.

Desulfovibrio desulfuricans :
The project also seems to 'blame'  Desulfovibrio desulfuricans bacteria as the cause of degradation of choline to TMA. This is the first time I have heard of this connection. It is interesting because it has been a bacteria of suspicion and is mostly known for producing hydrogen sulfide (H2S) from sulfates. Many people with metabolic malodor and TMAU report of smelling of 'rotten egg' which H2S is one known possible source of this smell.           

3 comments:

Ruy C. T. said...

This is a great news. I hope to do the same thing only working in the digestive system or stomach.

Apr 3, 2015, 9:20:00 AM
Anonymous said...

I hope that these students continue to one in their research to possibly find the cure for this condition, because it seems like the researchers and experts that we have working on this right now, is really slow in giving the people any bit of info, whether being good or bad, i mean people have to right to be updated on how things are goin. Good job students, and continue to keep up the good work...god bless u

Apr 3, 2015, 4:51:00 PM
Anonymous said...

God doesn't exist!

May 22, 2015, 6:08:00 PM
Post a Comment