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Sunday, December 20, 2015

DMB reduces trimethylamine gut formation

From press release 
Now, the team has identified a naturally occurring inhibitor called DMB – 3,3-dimethyl-1-butanol, found in some cold-pressed extra virgin olive oils and grape seed oils – that reduced levels of TMAO and reduced atherosclerosis in mice
New TMAO paper by Dr Hazen et al at Cleveland Clinic
Their 2011 paper suggested TMA-oxide may be main cause of CVD
Since then looking for therapies
Main aim seems to have been to stop TMA formation in gut
Looks like they have been trying various candidates to stop TMA formation
This paper suggests 3,3-dimethyl-1-butanol  (DMB) inhibits TMA formation in gut
DMB is a natural compound found in certain foods and drinks
Perhaps DMB will be the compound in the OTC product they plan to sell via Proctor & Gamble
If you think TMA is the sole reason for your malodor, this could be a future therapy for 'TMAU'

TMA inhibited by DMB research : link to full paper
Cleveland Clinic official press release : link
UK Daily Mail article : link
Prof Colin Dolphin comment : link  

In 2011 Dr Stan Hazen et al at the Cleveland Clinic first put forward the hypothesis that TMA-oxide may be a strong (perhaps strongest) biomarker for CVD. Since then it seems they have been looking at ways to deal with this. It seems their main aim was to stop trimethylamine formation in the gut. It looks like they have been looking at many compounds that may do this, and have now published of finding a compound, 3,3-dimethyl-1-butanol (DMB), which naturally occurs in some foods and drinks, which seems to inhibit TMA formation in the gut (e.g blocks/interferes with the choline to TMA process created by enzymes in gut bacteria).

It is not clear if this discovery is at an advanced stage or if they have just proved the concept and that DMB may not even be the ideal compound. We do know they signed an agreement with Proctor and Gamble in August to produce an #over the counter' product in the future that will help with 'TMAO management'.

So at the moment we know little other than they have proved the concept of blocking/reducing TMA formation in the gut, but will have to wait to see what happens next. Obviouisly if it blocks TMA formation then it should be a therapy for TMAU too (if you feel that TMA is the sole compound causing your malodor). With the therapy meant for Heart disease and perhaps other seriouos metabolic disorders, we can assume a lot of money has gone into this research and probably will in the future.

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2 comments:

Anonymous said...

Thank you for posting, this is very interesting. Hopefully it can benefit us in the near future

Dec 24, 2015, 7:51:00 AM
kelly carroll said...

I don't know which parent I inherited this condition from. I do know that my dad died from cvd at 75. This cold be the reason. I wish I was a scientist so that I could help find a cure. Every time I buy a lottery ticket I think to myself...please God let me win so I can donate to rare disease issues. FIRSTLY a cure for us tmau sufferers. Secondly everything else. That is all I ask.

Jan 18, 2016, 10:42:00 PM
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