Admin Control Panel

New Post | Settings | Change Layout | Edit HTML | Edit posts | Sign Out

Labels

March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country
MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
rareconnect.org TMAU

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed
Follow MeBOResearch on Twitter

Blog Archive

Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

https://www.meboblog.com/2023/01/denver-tmau-test-survey-tbc-who-it-is.html

Wednesday, February 17, 2016

ClinicalTrials.gov approval MEBO Metabolomic Study for Malodor

a  PATIENT ADVOCACY International campaign to research SYSTEMIC BODY ODOR AND HALITOSIS

A 501(c)3 Public Charity, USA
A Not For Profit LTD Company, England and Wales


Approved Exploratory Research Study

Exploratory Study of Relationships Between Malodor and Urine Metabolomics
(ID: 201505010014MEBO/ NCT02683876)

Clinicaltrials.gov is maintained by the National Library of Medicine (NLM) at the National Institutes of Health (NIH). This site receives over 200 million views per month and 65,000 unique visitors daily.
I am very excited to announce that on February 16, 2015, the new MEBO Research sponsored clinical trials, the Exploratory Study of Relationships Between Malodor and Urine Metabolomics (ID: 201505010014MEBO) has been approved and assigned research number NCT02683876 by the U.S. Clinical Trials.gov Protocol Registration and Results System after they reviewed the protocol information that fulfilled their requirements and received the human subjects review board approval from the MEBO Institutional Review Board (IRB).

This information can be found on the Clinical Trials website at,
https://clinicaltrials.gov/ct2/results?term=NCT02683876&Search=Search

MEBO's Scientific Director, Irene Gabashvili, PhD. is representing MEBO as the registered U.S. Principal Investigator of this study, and she is collaborating with the registered Principal Investigator, David Wishart, PhD, of the Metabolomics Innovation Centre (TMIC) of the University of Alberta, in Edmonton, Canada.

Clinicaltrials.gov is maintained by the National Library of Medicine (NLM) at the National Institutes of Health (NIH). This site receives over 200 million views per month and 65,000 unique visitors daily.

Metabolic profiles will be identified using the metabolomics equipment located in the NMR, HPLC, and MS facilities of the Metabolomics Innovation Centre (TMIC).
In this study, metabolite profiling analysis will be carried out on urine samples of individuals with malodor conditions related to metabolism inefficiencies. Metabolic profiles will be identified using the metabolomics equipment located in the NMR, HPLC, and MS facilities of the Metabolomics Innovation Centre (TMIC). Multivariate statistical analyses will be used, as well as other approaches to mine complex data from heterogeneous sources.

PURPOSE OF THIS STUDY


The pilot study is commencing involving participants who reside in Canada and suffer from a malodor condition, and based on results, will expand to include sufferers from other countries.
FOR NUTRITIONAL AND METABOLIC DISEASES
RESULTING IN MALODOR CONDITIONS

The purpose of this study is to identify metabolic signatures associated with malodor conditions. The investigators will perform state-of-the art metabolomics tests and bioinformatic data mining to explore whether conditions leading to malodor can be screened by metabolomic profiling of urine samples.
So we are ready to start the study and are excited to work with Dr. Wishart.

PRIMARY OUTCOME MEASURES


Differences in metabolite concentrations measured by mass spectrometry, comparing urine samples from individuals with malodor issues, and age-matched healthy controls. The investigators would like to validate if urine metabolomic profiling can be used for identifying key metabolomic signatures associated with malodor.

SECONDARY OUTCOME MEASURES


Correlations between urine biomarkers and frequency/severity of malodor symptoms (questionnaires). The investigators will comprehensively analyze the ability of metabolite levels to discriminate frequent and severe from non-severe malodor symptoms.

GROUPS/COHORTS


  1. Subjects with malodor: individuals with self-reported odor issues suspected to be associated with microbial imbalance on or inside the body and inefficient metabolism as evidenced from other laboratory tests.
  2. Healthy control: individuals not complaining of uncontrollable or unpredictable malodor episodes.

RECRUITMENT


All recruitment will be performed exclusively by MEBO.
All recruitment will be performed exclusively by MEBO. Anyone interested in participating in this program can express interest by email to maria.delatorre@meboresearch.org. Please provide your legal name, address, and email address where you will be contacted to be invited to participate in the study.
At the present time, the pilot study is commencing involving participants who reside in Canada and suffer from a malodor condition, and based on results, will expand to include sufferers from other countries. If you qualify and are interested in being a participant in the pilot study and have not yet been contacted, please express interest to the email above.

CONFIDENTIALITY


In an effort to maintain the integrity of the study, the staff at TMIC will not have any of your personal information, and you may be disqualified from the study if you contact the lab directly and divulge personal information.
Confidentiality is of the utmost important to MEBO and to this study. All information will remain confidential, and no one outside the MEBO staff in charge of this program will not have access to any of your personal information. In an effort to maintain the integrity of the study, the staff at TMIC will not have any of your personal information, and you may be disqualified from the study if you contact the lab directly and divulge personal information. All contact must be made through MEBO exclusively. Your cooperation in this matter would be greatly appreciated.



María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
www.mebo.com.br/
MEBO's Blog (English)
El Blog de MEBO (español)

MEBO Brasil - Blog (Portuguese)



SUPPORT THE MEBO MISSION: Click Amazon button at right sidebar of this blog when shopping online for the holidays
at no extra cost to you.
MEBO gets small commission from Amazon.


Please use your credit card to make your donation to MEBO.


Subscribe for latest posts : Enter your email address:

Delivered by FeedBurner


A EURORDIS and NORD Member Organization

4 comments:

Anonymous said...

Maria is this related to Trinzyme in anyway? Wouldn't this exploratory study benefit Trinzyme?

Feb 17, 2016, 9:15:00 PM
Stephanie said...

What a great study! I can't wait to be a part of it. Not only will it guide us to identify other malodor diseases it can also let us know what to avoid in our diet, if low choline isn't working for us.

Feb 21, 2016, 4:03:00 PM
Maria de la Torre said...

Hi Anonymous,

No, the MEBO Metabolomic Profile research is not related to Trinzyme in any way. Trinzyme is concentrating more a treatment forTMAU, whereas, the MEBO metabolomic research is all about identifying metabolites and their levels in the urine to compare them to participants that do not suffer from odor conditions. The hope of carrying out this exploratory study is to create a metabolomic profiles of one or more odor conditions. This will probably include TMAU, as well as others yet to be identified, which we hope this research will do.

It's impossible to control or cure a condition that has not been discovered (identified). This will be step #1.

Feb 29, 2016, 2:53:00 PM
Maria de la Torre said...

I agree Stephanie. And more importantly, it will guide sufferers who do not have TMAU towards a better targeted protocol, as opposed to a low choline diet, which they don't need and is bad for their liver.

Feb 29, 2016, 2:54:00 PM
Post a Comment