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Wednesday, December 21, 2016

Asian herbal mushroom and FMO3 induction

A Korean research paper last week claims that an asian mushroom commonly used by Korean Herbalists could induce FMO3.

mushroom : Phellinus baumii 

Korean paper (University of Seoul, Seoul, Korea):
Korean herbal mushroom induces FMO3 in mice in research paper.

Quote :
"PBE was responsible for the induction of Fmo2, Fmo3, and Fmo4 expression. PBE also accelerated the metabolic clearance of carbendazim in vivo and so could be applied to the detoxification of xenobiotics such as drugs, pesticides, and nicotine."
pubmed link to abstract


Keeping in context :
This is a one-off paper.
One-off papers come and go about almost any health aspect (i.e. butter good/bad ).
Perhaps their expertise is in Korean Herbalism.
It's unknown how the mushroom may affect other enzymes etc.

FMO3 Induction as a potential therapy :
The usual teaching is that FMO3 cannot be induced/inhibited. This is despite the fact there have been papers showing FMO3 inhibition (indoles in cruciferous veg, during menstrutation).

So this is possibly the first time a 'non-pathogenic' compound has been shown to INDUCE FMO3. (a very cancerous compound previously was, again a one-off paper.

It has been speculated that FMO3 INDUCTION could be a potential therapy in that it may increase function by a few % (e.g. 10%, 20%). So if a harmless compound(s) could be found, it may be a potential therapy for 'text-book' FMO3 deficiency (not sure about those with TMAU2. Perhaps indirectly, but seems unlikely).

A current thought on this paper :
People in the TMAU community often complain of side-effects from potential 'FMO3 therapies'. FMO3 probably alters many compounds derived from plants. FMO3 has been part of living things probably from early evolution. A theory is that FMO3 was developed to dela with plant poisons (in the animal/plant evolution warfare). So with FMO3 deficiency it may be a case of the meat/poison saying.
So any lead in this area should probably be viewed with caution, perhaps expecting it to do more worse than good.

Wikipedia entry for FMO's 
"FMOs have gained a lot of attention in drug development since these enzymes are not readily induced or inhibited by the chemicals or drugs surrounding their environment.[14] CYPs are the primary enzymes involved in drug metabolism. However, recent efforts have been directed towards the development of drug candidates that incorporate functional groups that can be metabolized by FMOs. By doing this, the number of potential adverse drug-drug interactions is minimized and the reliance on CYP450 metabolism is decreased."

Cashman paper 2006 
 "In contrast to cytochrome P450 (CYP), FMO is not easily induced nor readily inhibited"


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1 comments:

Anonymous said...

Were in the USA can I purchase the herb

Dec 26, 2016, 5:47:00 PM
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