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Monday, June 12, 2017

The People behind the P&G TMA reducing supplement

Readers have been aware since 2015 that a trimethylamine reducing therapy has been on the cards. Here is some background (and guesswork) to the 'therapy' (speculated to be a supplement).

The 2 organisations involved  :
Cleveland Clinic (Innovations)
Procter & Gamble

Cleveland Clinic :
Has a long history of being a pioneer in heart diesease research and treatment.

Dr Stanley Hazen (lab) :
Dr Stanley Hazen is one of the world's leading Heart Disease doctor's and researcher.

In 2011 his lab (Hazen et al) put forward a paper saying that Trimethylamine-n-oxide (TMAO) may be a strong causal factor for developing Heart Disease.pubmed ).
One obvious potential therapy was to stop gut microbes altering the likes of choline into TMA. One possible way to do this would be to interfere with the choline-TMA metabolism.
This seems to be what the patented product will do.
The lab has released many TMAO-CVD papers since 2011.
It seems most of the papers are have Dr Tang as lead researcher.
In this case the end product will probably come under the Cleveland Clinic INNOVATIONS dept. Or Cleveland Heartlab.

Procter & Gamble :
P&G is one of the biggest manufacturer and brand for household products, including some nutrition products.

It seems Cleveland ( Innovations ) have teamed up with P&G probably mostly under a licence agreement whereby P&G are the sellers of the product.

P&G Nutrition products :
A guess is that the TMA-inhibiting product will be sold as part of the P&G Nutrition range.
Perhaps as part of the 'Meta' range.
P&G Nutrition online shop
P&G current heart health product

Product patent (current version Dec 2016) : link

Inventor names on the patent :
Garcia-garcia, Jose Carlos (Cincinnati, OH, US)
Hazen, Stanley Leon (Pepper Pike, OH, US)
Wos, John August (Mason, OH, US)

Garcia-garcia, Jose Carlos.
Principal Scientist at Procter & Gamble

Hazen, Stanley Leon

Wos, John August
Principal Scientist at Procter & Gamble

When will we hear the latest news ?
Probably in a press release. Until they are ready, they will keep all info secret.
One idea is to follow Cleveland Innovations on Twitter.
But it will likely be major news when it is available.

Aug 2015 Press Release

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