MEBO Private Facebook Group
to join : contact
maria.delatorre@meboresearch.org

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact map@meboresearch.org

MEBO TMAU urine test

MEBO Research
TMAU Urine Test
United States only
PROGRAM IS PERMANENTLY SUSPENDED AS OF 2 MAY 2017

Click here for
REQUISITION FORM
Incomplete applications
will NOT be processed

SEE UPDATES HERE

1
test
$150 plus
shipping costs
2
tests
$250 plus
shipping costs

TWO PAYMENT PLAN OPTION
Send email to maria.delatorre@meboresearch.org to arrange, AFTER filling out Requisition Form, please.

Test analysis performed in batches of 20 or more

DATE: 2 MAY 2017
Currently on : PROGRAM IS TEMPORARILY SUSPENDED

Samples analyzed since June 2012 :
352
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
BannerFans.com
RESEARCH DETAILS

DONATIONS THRU 31-NOV-2016:
£ 943.03/GBP
$ 568.00/USD

TOTAL at today's ROE
£0.80/GBP = $1.00/USD

£1,398.07 = $1,745.14

MEBO UK PAYPAL FOR TRINZYME

********
MEBO US PAYPAL FOR TRINZYME

Your currency will be automatically converted to USD or GBP by PayPal.

Option: pay with your credit card instead of PayPal account by clicking on either Donate button above.

Popular Posts (last 30 days)

Upcoming get-togethers


Let us know if you want a meetup listed

Subscribe to Blog

Enter your email address:

Delivered by FeedBurner

You will be sent a verification email

Subscribe in a reader

Blog Archive

Monday, September 18, 2017

Could choline deficiency go with TMAU ?

A new paper seemed to show that MICE that had a gut flora rich in tma-producing bacteria were prone to having BLOOD CHOLINE DEFICIENCY, and exhibited symptoms associated with choline deficiency.

It raises the questions :
1. If a human with TMAU1 or TMAU2 (before diagnosis) is prone to develop long-term choline deficiency due to TMA bacteria 'eating' the choline.
2. If someone then follows the low choline diet protocol is choline deficient, or even moreso.    

Choline plasma testing should be part of a TMAU 'profile' test, but it seems choline blood testing is a very difficult test to find from a health testing service, if at all.
It was only recently upgraded to an 'essential' nutrient, but still seems to be largely ignored despite known to be crucial for pregnant women, but probably still underestimated for everyone.

Some roles choline plays :
1. It is a main 'lipotropic' factor for the liver, in essence being a fat decongestant. Perhaps someday it will be regarded a factor in 'non-alcoholic fatty liver', or perhaps TMAU people are prone to NAFLD.
2. It is a main methyl donor.
3. It has an important role in the brain.

What the study did :
The study seemed to put 'gut-sterile' mice in 2 groups. 1 group was given  tma-producing bacteria. Group 2 was given the same bacteria that had been genetically altered to not 'cleave' choline into tma.
It seems group 1 developed choline deficiency symptoms, while Group 2 did not.

Human TMAU - Choline dilemma :
There must be some thought that this might be true for TMAU humans too.
Only a choline blood test could probably confirm this, but is currently difficult to access.

Any form of choline less suitable for gut bacteria ?
The ordinary form of choline seems to be ideal for tma-bacteria.
There has been some 'talk' that perhaps choline in the form phosphatidylcholine (PPC) is harder for some types of gut bacteria to break down, but nothing can be confirmed of this.
Lecithin is mainly PPC (and less expensive than pure PPC), but lecithin contains other things (perhaps normal choline ?).
IN THE END, THIS ALL MAY BE POINTLESS OR MAKE THINGS WORSE, THE BESAT OPTION WOULD BE A CHOLINE BLOOD TEST.

Choline testing campaign :
Ultimately probably the best option would be a campaign to access the choline blood/plasma test. Since none of the main test labs seem to test for it, it's hard to know where to look.

One common test that may be of some use is a liver untrasound. This may show some signs of FLD. But it seems FLD may be common in Westerners due to the diet etc (just that for most it won't get so bad as to give symptoms).
It would be interesting to see if non/symptomatic NAFLD was a pattern in TMAU.

Interventions to stop gut-flora altering choline :
In the paper they use sterile mice and give group 2 a bacteria modified to not have the choline-tma enzyme.
In humans probably the best option will be Hazen/Cleveland/P&G microbe tma-blocker that is currently being researched (release date unknown) as this will simply block the formation of tma in the gut.

2017 Paper : Choline in mice

wikipedia :
Choline
Lecithin 
Phosphatidaylcholine

Pauling Institute : Choline
      

get New Posts by EMAIL : Enter your email address :



A EURORDIS and NORD Member Organization

0 comments:

Post a Comment