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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU UK end total:262
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TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


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London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Saturday, April 6, 2019

Ubiome article about TMA bacteria

Ubiome TMA level example
Ubiome, the innovative Microbiome DNA testing company that MEBO is currently undergoing a joint-study with (about the microbiome of our community) have their own blog.

Their latest post is about the inclusion of an estimation of Trimethylamine levels in your microbiome via their gut microbiome DNA test.
Link to Ubiome TMA blog post

From Ubiome blog post about trimethylamine in the gut :

Choline and carnitine on their own aren’t bad. In fact, choline is an important nutrient that helps your body form stable cell membranes. Carnitine is manufactured by your own body and helps your cells convert fat into energy.

However, certain gut microbes may make these substances problematic for you. When you eat foods containing choline and carnitine, these gut bacteria digest them and produce the compound trimethylamine (TMA). TMA is absorbed into your bloodstream and carried to the liver, which converts it into trimethylene N-oxide (TMAO).

High concentrations of TMAO in your blood are associated with atherosclerosis, cardiovascular disease, and an increased risk of death in patients with stable coronary artery disease. There’s also evidence that TMAO levels increase as kidney function decreases.

The main reason they have started to include TMA estimation will be to do with the Cleveland Clinic theory about TMA-Oxide being associated with heart disease.
But perhaps this was inspired bythe test study program MEBO and Ubiome currently have (making Ubiome aware of TMA).
Whatever the reason, it's good news for TMAU people, as it's another way to monitor TMA levels in the gut (but keep in mind it is an estimation).

Ubiome TMA level estimation :
What Ubiome do is estimate the level of TMA generated from your microbiome by looking at the bacteria they think will generate TMA.
It's not known how much knowledge the world currently has about TMA production in the gut, but it's a very welcome start and surely knowledge will grow (about a volatile that no-one had interest in up until recently).
Re TMA, Ubiome are way ahead of mainstream medicine in taking an interest in TMA (and indeed, in 'fecal body odor' and all forms of malodor that affect our community)   

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