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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country
MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
rareconnect.org TMAU

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Blog Archive

Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

https://www.meboblog.com/2023/01/denver-tmau-test-survey-tbc-who-it-is.html

Saturday, April 6, 2019

Ubiome article about TMA bacteria

Ubiome TMA level example
Ubiome, the innovative Microbiome DNA testing company that MEBO is currently undergoing a joint-study with (about the microbiome of our community) have their own blog.

Their latest post is about the inclusion of an estimation of Trimethylamine levels in your microbiome via their gut microbiome DNA test.
Link to Ubiome TMA blog post

From Ubiome blog post about trimethylamine in the gut :

Choline and carnitine on their own aren’t bad. In fact, choline is an important nutrient that helps your body form stable cell membranes. Carnitine is manufactured by your own body and helps your cells convert fat into energy.

However, certain gut microbes may make these substances problematic for you. When you eat foods containing choline and carnitine, these gut bacteria digest them and produce the compound trimethylamine (TMA). TMA is absorbed into your bloodstream and carried to the liver, which converts it into trimethylene N-oxide (TMAO).

High concentrations of TMAO in your blood are associated with atherosclerosis, cardiovascular disease, and an increased risk of death in patients with stable coronary artery disease. There’s also evidence that TMAO levels increase as kidney function decreases.

The main reason they have started to include TMA estimation will be to do with the Cleveland Clinic theory about TMA-Oxide being associated with heart disease.
But perhaps this was inspired bythe test study program MEBO and Ubiome currently have (making Ubiome aware of TMA).
Whatever the reason, it's good news for TMAU people, as it's another way to monitor TMA levels in the gut (but keep in mind it is an estimation).

Ubiome TMA level estimation :
What Ubiome do is estimate the level of TMA generated from your microbiome by looking at the bacteria they think will generate TMA.
It's not known how much knowledge the world currently has about TMA production in the gut, but it's a very welcome start and surely knowledge will grow (about a volatile that no-one had interest in up until recently).
Re TMA, Ubiome are way ahead of mainstream medicine in taking an interest in TMA (and indeed, in 'fecal body odor' and all forms of malodor that affect our community)   

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A EURORDIS and NORD Member Organization

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