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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Sunday, November 29, 2020

UK lab blocks TMA formation from CARNITINE

The 2 main sources of Trimethylamine in humans (via diet) seem to be (not much research) bacterial enzyme degradation of diet CHOLINE and CARNITINE. 

Choline degradation seems to be the main source, say 80-90% ?? (pure guess).

The upcoming Cleveland / Procter & Gamble tma-blocker pill looks to mainly block the choline path (though we don't know really. Maybe it blocks both?).

Now a (small) UK Uni lab (University of Warwick) which looks at bacterial enzymes has blocked bacterial degradation of Carnitine to TMA.

Bacterial enzymes :
Bacteria (and archeae etc) have enzymes that can break things down.
In relation to TMA formation in the human gut, there seems to be 2 enzymes that can break down TMA precursors :
cut-C enzyme for Choline to TMA ?
and now this lab says CntA enzyme for Carnitine to TMA.

So the lab seems to have blocked CntA enzymes from breaking down Carnitine.

It seems they are at the first stage, and a long way from producing a carnitine-TMA blocker pill (if ever). Including the need for funding (not got money on tap like Cleveland Clinic).

It's also unknown how big an impact a carnitine-tma blocker pill would have, as most of the TMA seems to be from choline pathway.

The lead researchers write in an email :

"Thank you for your email regarding our recent work on the Carnitine to TMA formation pathway.

Yes, this work complements the Choline pathway in that we have a crystal structure model of the carnitine degrading “CntA” enzyme with a better understanding of how carnitine is recognised by the enzyme. And yes, the inhibitors we report are the first of their kind against CntA.  

We envisage, this work establishes a strong platform to progress the research to improve the inhibitors. We are eagerly awaiting to hear if we have been successful in securing follow up funding to progress this work. We’d be looking to test the inhibitors against a wider range of bacteria representative of the gut microbiome and demonstrate that we can indeed inhibit carnitine breakdown with such inhibitors in the gut microbiome. We’d also like to further develop the inhibitors for potency and improved efficacy against the bacteria responsible. Ideally, a combo Carnitine + Choline blocker therapeutic would be the ultimate realisation to treat TMAU in the long run.  

Thank you once again for reaching out, it is a pleasure to know our work is noticed and appreciated; reinforcing our research motivations."

Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition and inter-subunit electron transfer
Mussa Quareshy1, Muralidharan Shanmugam2, Eleanor Townsend3, Eleanor Jameson3, Timothy D.H. Bugg4, Alexander D Cameron3 and Yin Chen3
1School of Life Sciences, University of Warwick, United Kingdom
2University of Manchester, United Kingdom
3University of Warwick, United Kingdom
4Department of Chemistry, University of Warwick, United Kingdom


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2 comments:

Anonymous said...

UK BLOCKS TMA
If the time comes hope the pill can easily bought online because I am from canada.....ut is useless if its too expensive and difficult to buy.....

And can anyone update me of the pillthey said fluxovas pill that can cure or lessen tmau...is this true and effective or just falls hope again...

Because I am trying resveratrol with grape seed extract and skin....because they said it has the same ingredients...

Please let me know thanks for your help


Nov 30, 2020, 10:17:00 PM
Grzegorz Sawicki said...

How much costs this therapy ?

Dec 11, 2020, 6:50:00 AM
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