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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Tuesday, July 11, 2023

Unleashing Synthetic Biology to Cure TMAU

Trimethylamine (TMA) is a volatile tertiary aliphatic amine primarily derived from dietary consumption. In the human body, this compound typically undergoes metabolism by the enzyme flavin-containing monooxygenase 3 (FMO3) into a less malodorous byproduct - trimethylamine N-oxide (TMAO). 

While microbiome often assist those with less efficient digestive genes to metabolize food, as observed in cases of lactose intolerance, FMO3 enzyme is an exception as it is not naturally produced by bacteria, only in humans, primates and some mammals.

Fortunately, a similar enzyme, Trimethylamine monooxygenase (TMM), can catalyze the oxidation of TMA to TMAO. Notably, this enzyme is found in the marine bacterium Ruegeria pomeroyi.

Building on the groundbreaking efforts of a preceding team that successfully synthesized TMM from Ruegeria pomeroyi and expressed it in E. coli, this year's Florida State University (FSU) iGEM team is poised to expand this research further. Leveraging promoters crafted by previous FSU iGEM teams (from 2018 and 2020) and armed with a FMO3 CRISPR/Cas9 Plasmid, they are geared up to take the reins and explore new frontiers in the treatment of TMAU using synthetic biology.

With the initiation of this year's competition, the FSU team is now racing against time. With two months to see their project to completion, they're equipped with three plasmids, a wealth of knowledge, and a strong determination to discover a therapy for TMAU, a metabolic disorder that has no cure.

The process won't be easy. The late nights in the lab, the countless trials and failures, and the endless tweaking of protocols are all part of this journey. But the prospect of developing a therapy for TMAU and pushing the boundaries of synthetic biology, make the journey worth every challenge.

Today we learned about some of the details of the project from Human Practices leads Christian Suastegui and Colton Keib. Other student members of the team are Graeme Pugsley, Eva Lobaton, John Amos, Jolene Jones, Hanna Yilmaz-Rodriguez, Sonali Shakya, Vicenzo DeVito and Prerna Ravinder.  The team lead is Elizabeth Moore. Read FSU blog and our updates and stay tuned as we follow this team's exciting adventure. 

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Anonymous said...


Jul 12, 2023, 2:50:00 AM
Karen said...

Exelente noticia gracias Mebo y al equipo de la universidad de florida.

Jul 12, 2023, 9:53:00 PM
Anonymous said...

Any word yet?

Sep 11, 2023, 11:52:00 AM
Anonymous said...

Does anyone know a nutritionist/ doctor that will help me get the TAMU test in Colorado? I am in Miami Florida. Thank you

Sep 28, 2023, 6:08:00 PM
Anonymous said...

약은 언제쯤 개발 되나요?

Oct 8, 2023, 2:36:00 AM
MitchR said...

Is there an update on progress? So many suffering and isolated. Thank you for all you are doing!

Nov 18, 2023, 7:41:00 PM
Kisha said...

What's the update on treatment for tmau

Dec 19, 2023, 8:17:00 PM
Roma Smith said...

How can we get the test dose in every state and as well as at birth . This way doctors don’t look at us as trying to diagnose ourselves.

Mar 26, 2024, 12:46:00 AM
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