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MEBO Research public TMAU database |
Nigel Manning, the Principal Clinical Scientist of Dept. Clinical Chemistry at Sheffield Children's Hospital and the only current trimethylaminuria phenotype tester in the UK did kindly give MEBO Research a PDF document a while ago that contained much appreciated anonymous information on his testing results of up until 2009.
Sheffield TMAU results up to 2009. Those to the right are genetic TMAU. Above the line is trimethylamind (TMA) overload. According to the reference ranges that Sheffield have set |
This would also help people understand the different reference ranges and protocols of the labs currently testing. For instance, it is our understanding that the Denver lab expects a person to convert 92% of TMA to trimethylamine N-oxide (TMAO), whereas Sheffield only expects around 82% to be converted from TMA to TMAO. Since TMAU is such a 'neglected' problem, so few labs test for it and there is much more yet to be understood.
The database is held in a Google Docs spreadsheet, and the public version will be a PDF document hosted on the MEBO Research website that will be regularly updated.
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