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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

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Update : discount is suspended
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

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Blog Archive

London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
click to read more

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, September 9, 2019

Update MEBO Gut Microbiome Study

Click on icon
As we wait for the results from uBiome of Batch #4 of the MEBO Clinical Trial, Dynamics of the Gut Microbiotal in Idiopathic Malodor Production, which explores the microbial basis of systemic malodor and PATM conditions, Irene Gabashvili, PhD., Principal Investigator has written a few posts in her Aurametrix Blog, pointing out various findings as the study unfolds. In her previous posts, Irene observed epulopiscium and blastocystis hominis as potential culprits of conditions in MEBO sufferers. In her most recent post (Sep 4, 2019), she observes a third group of MEBO sufferers (only 10% of participants) with elevated levels of Alloprevotella group of microbes (see figure above), which seem to be making symptoms worse. "This bacteria is an oral bacteria associated with gingivitis and periodontal conditions..."
The Anna Karenina principle (AKP), in the context of metabolic disorders, would mean that an uncompensated deficiency in any one of important enzymes, or presence of any one of pathogenic microorganisms, dooms the person to having the MEBO/PATM symptoms.

We note that neither of microorganisms identified in our study is a true pathogen. These could be opportunistic microbes taking advantage of opportunities not normally available, such as weakened enzymes or disrupted gut microbiota. The microbes we see could be also symbionts of pathogens or indicators of inflammation and dysbiosis.
bhttps://aurametrix.com/blog/akpb

For more indepth explanation on Alloprevotella and the chart above, please refer to the post in Aurametrix.

Irene tells us that this gut microbiome study is the first to pursue the root cause:
Our microbiome trial is the first study where we can actually group participants based on the root cause, independently of their diets (unlike our Biolab and Wishart metabolome studies).

Full paper (Biolab), "Community-led research discovers links between elusive symptoms and clinical tests," on MEBO-Biolab study,Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis : NCT02692495

Full paper (Wishart), "Identifying subtypes of a stigmatized medical condition" on Exploratory Study of Relationships Between Malodor and Urine Metabolomics: NCT02683876


MEBO Dynamics of the Gut Microbiota 
in Idiopathic Malodor Production


This MEBO clinical trial is in its final stages of data analysis and will soon publish the conclusion. Meanwhile, the updates on findings by Irene Gabashvili, PhD., Principal Investigator, can be found in the following posts in the Aurametrix Blog:
  1. Alloprevotella: September 4, 2019
  2. Epulopiscium: August 19, 2019
  3. Friends and Stars: August 14, 2019
  4. PATM and TMAU: August 5, 2019
  5. Feeding microbiomes: July 21, 2019
  6. Blood type: June 2, 2019
  7. First 41 results: November 21, 2018
  8. Press Release: November 28, 2018
  9. What we hope to learn: June 27, 2018
  10. MEBO Microbiome Study: June 215, 2018
  11. Microbes of anti-social odor: March 14, 2018
  12. Crowdsourcing precision medicine: February 23, 2018
We are most grateful to uBiome for their very generous research grant and to Irene for her dedication and leadership in this research study.
María

María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
www.mebo.com.br/
MEBO's Blog (English)
El Blog de MEBO (español)
MEBO Brasil - Blog (Portuguese)



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A EURORDIS and NORD Member Organization

uBiome restructuring not affecting MEBO study

On September 4th, MEBO received an email from the Research and Collaborations Lead scientist, who has been providing us with ongoing support on the MEBO Clinical Trial, NCT03582826, Microbial Basis of Systemic Malodor and PATM Conditions, a research study funded by a uBiome research grant. In her email, she informs us that on the previous day, uBiome filed for Chapter 11 Bankruptcy protection. She further explains:
uBiome filed for Chapter 11 Bankruptcy protection. This a necessary step in our ongoing restructuring and will allow our business to move forward as a whole. I wanted to ensure you that business is currently continuing as normal, and our laboratory operations will continue.

We are dedicated to continuing our research partnerships as they are an essential element of the future of the company, and I want to emphasize that our support of your ongoing studies will not be affected.

In addition, I asked the uBiome scientist why the new TMA results category was removed from each participant's personal online report, to which she replied:
I am so sorry that it has been removed, I know it was useful for you and the community.

In the last few weeks/months we have been updating Explorer to make sure what we are saying is scientifically valid and can stand up to scrutiny. I am not on the product team so I was not involved in the decision, but the decision to remove that was most likely based on what they felt was substantial scientific evidence to be able to report those results.

She added that she will mention it again to the product team when they make more updates.

At the present time, uBiome continues to offer the same Gut Explorer test used for the above mentioned MEBO clinical trial.

MEBO Dynamics of the Gut Microbiota 
in Idiopathic Malodor Production


This MEBO clinical trial is in its final stages of data analysis and will soon publish the conclusion. Meanwhile, the updates on findings by Irene Gabashvili, PhD., Principal Investigator, can be found in the following posts in the Aurametrix Blog:
  1. Alloprevotella: September 4, 2019
  2. Epulopiscium: August 19, 2019
  3. Friends and Stars: August 14, 2019
  4. PATM and TMAU: August 5, 2019
  5. Feeding microbiomes: July 21, 2019
  6. Blood type: June 2, 2019
  7. First 41 results: November 21, 2018
  8. Press Release: November 28, 2018
  9. What we hope to learn: June 27, 2018
  10. MEBO Microbiome Study: June 215, 2018
  11. Microbes of anti-social odor: March 14, 2018
  12. Crowdsourcing precision medicine: February 23, 2018
We are most grateful to uBiome for their very generous research grant and to Irene for her dedication and leadership in this research study.
María

María de la Torre
Founder and Executive Director

A Public Charity
maria.delatorre@meboresearch.com
www.meboresearch.org
www.mebo.com.br/
MEBO's Blog (English)
El Blog de MEBO (español)
MEBO Brasil - Blog (Portuguese)



SUPPORT THE MEBO MISSION: Click Amazon button at right sidebar of this blog when shopping online for the holidays
at no extra cost to you.
MEBO gets small commission from Amazon.


get New Posts by EMAIL : Enter your email address :



A EURORDIS and NORD Member Organization

Thursday, September 5, 2019

Karen's MEBO Meetup : LONDON 7 Sept 11am

Karen from MEBO UK has a message :

Let's meet up before the summer ends! Everyone, as always, is very welcome.

SATURDAY 7TH SEPTEMBER 2019 from 11am onwards

AT 
ROYAL FESTIVAL HALL, SOUTH BANK LONDON
Belvedere Rd, Lambeth, London SE1 8XX

We will be at the seating area with tables in front of the foyer. The foyer and outdoor seating area are next to the fountains shown in the picture on the website:

Please call 07505 590972 if you can't find us, and be patient if you can't get through immediately.


hope you can come to meet up on Saturday at 11am at South Bank main entrance/cafe. I will only be going for 2 hours as I have to work at 2pm in a new job, but there will be many people there who will be staying until much later.


Other news ...
BO at work SURVEY ...

a_smith (author of “The Taboo of Body Odor Medical Conditions and Ecological Counternarratives.”) has set up a survey for those who have had negative experiences at work, It's posted on RareConnect
Link here

If you want to do the survey, this is the link:
https://www.surveymonkey.com/r/X6VK7KH

Best wishes,
Karen

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A EURORDIS and NORD Member Organization