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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country
MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
rareconnect.org TMAU

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Blog Archive

Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

https://www.meboblog.com/2023/01/denver-tmau-test-survey-tbc-who-it-is.html

Friday, March 24, 2023

Lactobacillus and Bifidobacterium

The effects of the most widely used probiotics, Lactobacillus and Bifidobacterium, on body odor are not universal and may vary depending on the individual. According to MEBO interviews conducted in 2009 with laboratories offering microbial testing, it was suggested that high levels of Lactobacillus (responsible for the odor of uncooked food waste) may not always be beneficial. Instead, they recommended incorporating probiotics such as Bifidobacteria or Saccharomyces boulardii, along with prebiotic fiber, into the diet to potentially help the MEBO population. D-lactate was one of the tests they offered to quantify overgrowth of bacteria in the small intestine. Nevertheless, D-lactate was elevated in less than 20% in less than 20% of MEBO and PATM groups, as per our early clinical trials.

Data from our microbiome study indicate that while there was a general trend of increasing levels of Bifidobacterium and Lactobacillus in individuals who achieve remission, less than 10% of participants needed to boost levels for both species in order to improve their condition. 

In line with previous knowledge, in MEBO/PATM population, Bifidobacterium (one of the first microbes to colonize the human gastrointestinal tract) was more common in younger individuals. About one third of the participants experienced lesser symptoms when increasing levels of their gut Bifidobacteria, another third benefited from more Lactobacillus and the remaining third felt better when increasing levels of Faecalibacterium prausnitzii (a butyrate-producing anaerobe typically associated with good health). 

Our findings suggest that individuals with the highest bacterial diversity don't benefit from increasing levels of Lactobacillus and Bifidobacterium, while those with low diversity levels do need more probiotic microbes in their system. 

The figure (probiotic data overlayed with the Figure from our published results on diversity and skin bacteria in the gut) demonstrates the complexity of these bacterial perturbations and emphasizes the need to consider more than the most known probiotic species when predicting which treatment will work best for reducing MEBO and PATM symptoms. 

Research has shown that the gut microbiome is far more complex than previously thought, with hundreds of bacterial species interacting in a delicate balance.  Therefore, focusing solely on Lactobacillus and Bifidobacterium may not be enough to promote a healthy gut microbiome for everyone. Besides, different strains of bacteria within the same species can have different effects on the body, and the effects of any given strain can depend on a variety of factors, including the individual's overall health, genetics, other strains in the microbiome, and diet. 

More in the latest Olfactics blog post

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Wednesday, January 25, 2023

Insights from Latest Animal Studies

While there is not enough research being done on treating metabolic body odor, there are plenty of studies that can be related to this topic. Scientific papers published in January are about goats, fish, fermented food and biological waste. 

Discover new findings on how intermittent fasting, fiber-rich diet, stress levels and certain gut microbes impact body odor in the latest Olfactics blog article

The first study discussed is about how intermittent fasting in fish can improve body odor by promoting the growth of beneficial bacteria and reducing the growth of odor-causing bacteria. 

The second study discussed is about how adding fiber to the diet can improve body odor in goats.  Reducing stress levels could help achieve similar results.  

Another study discussed how the composition of odorants in biowaste is consistent with the microbial composition, and that Acinetobacter is the dominant genus in uncooked food waste and this could contribute to strategies for odor control and abatement in municipal biowaste management systems.

Lactobacillus, commonly found in household kitchen waste, and Acinetobacter, associated with fish odor and odor in MEBO and PATM populations, were found to play a role in unwanted body odors. Stay tuned for our upcoming article where we will delve deeper into these findings and explore the complex relationship between gut microbiome and body odor, as found in the MEBO Gut Microbiome study

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Saturday, January 7, 2023

Denver TMAU test survey

A TMAU survey was posted on the rareconnect TMAU forum this week. 

The poster is a genetic counseling student working with the Children's Hospital Colorado's Biochemical Genetics Lab.
This lab does the only TMAU urine testing in the USA, so it's a big opportunity to voice your opinion on US TMAU testing.

The post says :

  Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU.


Denver CH was the 'discover' of TMAU(?) in 1970. But since then it has felt like a legacy test that is continued for prestige. For example, it can only be done via a Dr order and not on insurance, and any contacts on the website have been removed over the years, presumably to avoid public contact altogether.Maybe this survey is a sign they wish to serve the community.

Everyone is free to write whatever they wish. Meanwhile here are some points people can mention (or not) if they wish.

1. have the option of a CONSUMER TEST (where people can test direct and self-pay).
It's too hard to access.

2. Add more biomarkers (i.e. FMO3 substrates). Possibly TMA only spots 'severe' FMO3 Malodor cases. Sulfides are more likely. TMA is not the best biomarker ?

3. Set up a lab-community co-operation group ... e.g. Friends of Denver TMAU test.

4. Urine test only spots 'severe' cases ? Sheffield UK used to spot less severe cases until 2017, but then they changed to same method as Denver.

5. Why is there never TMAU2 cases, when in theory it's the most likely ?

6. Think about ease of testing ? Is dry ice realistic ? So many obstacles. UK seems to use acid preservative.

7. Gene test should probably be the first test to do. A saliva test like 23andme would be good.

8. TMAU test profile should include Choline testing.

There are so many other ideas. Feel free to let them know your view.       

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