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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Monday, December 5, 2022

Spanish Dr wants TMAU volunteers to try anti-TMAU 'fragrance'

Beatriz Mínguez is a young pediatrician working in the Gastroenterology, Hepatology and Nutrition Service of the Hospital Sant Joan de Déu in Barcelona. She is one of the protagonists of this story that will change the lives of people suffering from fish smell syndrome.. In fact, it has already changed the lives of several of his patients, two children, and a few volunteers – a teenager and three adults – who two summers ago signed up for a pioneering and collaborative project between the aforementioned hospital center. and the multinational perfume company Eurofragance, present in more than 60 countries

Specifically, they have developed a body lotion in cream with 1% fragrance, an ‘eau de toilette’. with 5% fragrance and a body serum with 2% fragrance. With the latter, greater fragrance retention and good moisturization is achieved, in addition to ease of application.

Mínguez recalls that it is are still looking for volunteers in which to test the effectiveness of the products, and that all those affected can get in touch via the following email:

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Thursday, November 17, 2022

New Peer-Reviewed MEBO COVID-19 study

Although systemic malodor is commonly overlooked by physicians, it constitutes a major problem for many otherwise healthy people. Yet, this condition has thus far eluded effective treatments or cures in many individuals. The number of potentially responsible SNPs, genes, microbes and related disorders is large and keeps increasing, overlapping with confounders of COVID-19.  

Decentralized observational study NCT04832932 compared MEBO participants to general populations in respect to their response to COVID-19 vaccines and SARS-Co-V2 infections. 
Body odor flareups were observed in about 10% of current or former malodor sufferers after vaccination, as preliminarily reported. This number was similar to flareups of other chronic symptoms in groups of participants with gastrointestinal and autoimmune disorders.  

Long-term worsening of body odor was observed by other researchers after COVID-19 vaccination in about ~1% of studied populations. Dry mouth leading to halitosis was 10 times more prevalent compared to flu vaccines. MEBO participants reported stronger reactions than general population pointing to genetic and microbiome influences beyond FMO3.  

A better understanding of systemic malodor conditions could offer leads for targeted therapies. Findings on genetic and microbiome overlaps between COVID-19 and MEBO could pave the way for precision medicine to address the unmet needs of odor sufferers.


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Friday, September 9, 2022

Owlstone UK breath test for Trimethylamine ?

Owlstone Medical in UK make 'clinical' breath sensors.

It seems they are working on one for 'chronic kidney disease' that will test 2 biomarkers of interest to the Metabolic Malodor community

1. Trimethylamine
2. Dimethylsulfide

It sounds like it may be a decent TMAU test.
So far it sounds like it isn't used clinically.

Maybe people can write to show interest, and to encourage them to make it a consumer test and perhaps a study for metabolic malodor ?

From the Owlstone blog (30 Aug 22) :

The compounds responsible for the ‘fishy smell’ are now known to be amines, but human breath contains a wide range of other VOCs which could prove to be useful biomarkers for kidney function. A number of recent studies have attempted to investigate the potential clinical value of these VOCs.

Candidate biomarkers
Trimethylamine (TMA) is one of the amines that is particularly responsible for the fishy smelling breath associated with kidney disorders. Healthy individuals metabolize TMA in the kidneys, forming urea and formaldehyde. Impaired kidney function allows TMA to build up in the blood stream over time, before being excreted, unmetabolized, on both breath and urine.

This strong link means that in the past TMA in blood plasma has been suggested as a kidney disease biomarker. However, blood sampling is invasive and burdensome, so Grabowska-Polanowska et al. investigated whether measuring TMA on breath could be a better option.3,4 Across two related studies they found TMA on the breath of CKD subjects but not present on the breath of healthy individuals. Other studies, such as Romani et al.’s work, have also adjudged TMA a potential biomarker for CKD.5 Further work is needed to validate an association between TMA levels and disease severity and identify a TMA cutoff value that could be used for diagnosing CKD.

TMA is an exogenous VOC (EVOC) that is present in foods such as fish and normally ingested as part of normal diet. This presents an opportunity for a study to investigate the use of TMA as an EVOC® Probe, in the same way that, at Owlstone Medical, we have explored the utility of limonene (a chemical in orange juice) as an EVOC Probe for liver disease.


Dimethyl sulfide
Romani et al.’s study found dimethyl sulfide to be moderately accurate in predicting disease status (AUC 0.740), though Obermeier et al found that patients and controls exhaled similar amounts of dimethyl sulfide.5,6 A possible confounding factor is that organosulfur compounds have been noted to increase as consequence of a subject’s age or concomitant conditions (such as diabetes), not simply CKD status.

Additional classes of VOCs have been tentatively associated with CKD, including amines, alkanes, aldehydes, and alcohols. Further work is required to elucidate the biological associations between VOC marker classes and validate VOC signatures of CKD that can be reliably translated into clinical care.


How can we help you?
As interdisciplinary specialists in breath, we have created Breath Biopsy® OMNI to be the most advanced solution for reliable global breath biomarker analysis. And, when you choose to work with us, your investigation is further supported by our extensive study design, management, and data interpretation expertise.

Our Breath Biopsy Collection Station has been developed to maximize your chances of discovering robust breath biomarkers by ensuring optimal sample collection. The ReCIVA® Breath Sampler and CASPER® Portable Air Supply have both been specifically designed to increase signal-to-noise in breath samples (previously a significant challenge), and collect standardized samples that ensure high comparability between patients, even over multiple sampling locations and longitudinal time-courses.

Developing a clinically useful test requires identification of the VOCs that can be linked to underlying biology and the specific disease of interest. Breath Biopsy OMNI uses TD-GC-MS with high resolution and high dynamic range, maximizing the number of VOCs that can be studied in your breath sample.


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