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MEBO TMAU urine test

MEBO Research
TMAU Urine Test
United States only
Click here for
REQUISITION FORM

SEE UPDATES HERE

1
test
$150 plus
shipping costs
2
tests
$250 plus
shipping costs

TWO PAYMENT PLAN OPTION
Send email to maria.delatorre@meboresearch.org to arrange, AFTER filling out Requisition Form, please.

Test analysis performed in batches of 20 or more

DATE: 11 NOV 2016
Currently on : BATCH #17
Program resumed July 2016
Samples analyzed since June 2012 :

314
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect
Herbal Hill
Deodorising Products
see this post
Herbal Hill site
Facebook Page

MEBO meetup map


Full details : https://goo.gl/TMw8xu
want listed ? contact map@meboresearch.org

Sonya's TMAU diet book

One of our group, Sonya McClinton, has written a 'low choline' recipe book. If you buy from Amazon through these links MEBO get a small % at no extra cost to the buyer


Amazon USA
38 sold

Amazon UK
14 sold
Don't have a kindle ? There are details on the right-side of the amazon pages how to download an app for smartphones, PC, or tablet. For Spain/Canada use the Amazon links in the left sidebar
BannerFans.com
RESEARCH DETAILS

DONATIONS THRU 31-NOV-2016:
£ 943.03/GBP
$ 568.00/USD

TOTAL at today's ROE
£0.80/GBP = $1.00/USD

£1,398.07 = $1,745.14

MEBO UK PAYPAL FOR TRINZYME

********
MEBO US PAYPAL FOR TRINZYME

Your currency will be automatically converted to USD or GBP by PayPal.

Option: pay with your credit card instead of PayPal account by clicking on either Donate button above.

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Tuesday, December 6, 2016

2nd UCL TMAU group session : official summary

2nd UCL TMAU group session
Summary of TMAU group session given by  psychologist Dr Monique Cloherty

On 22nd October 2016, the London NHS Adult Metabolism Unit (Charles Dent Metabolic Unit, UCL National Hospital for Neurology and Neurosurgery, London) held its second TMAU Group Meeting. This follows similar meetings this year at free healthcare Adult Metabolism Units in Dublin and NHS Birmingham, a breakthrough for the TMAU community.

Perhaps others can see if their regional Adult Metabolic Disorder Units might start TMAU group meetings.

Clinical Psychologist Dr Monique Cloherty hosted the session. The Charles Dent Metabolic Unit has kindly given this summary of the session  with Dr Cloherty for public release. :

Summary of TMAU session given by  psychologist Dr Monique Cloherty
The Charles Dent Metabolic Unit, London
22 Oct 2016


We got to know each other in small groups and shared our
experiences of TMAU.

We shared out stories of isolation. TMAU is very much a social
problem. A secret that we are constantly trying to hide. We told of
difficult events; name calling, bullying and not being believed that
have happened. People rarely spoke about a single event but a
sequence of events linked through time. We shared how TMAU made
us feel about ourselves, we can feel alone at times and paranoid.

We also heard about initiatives and steps that people have taken to
address the problems that TMAU can cause. We identified resources
and skills that made it possible:

Use of knowledge and being fearless
Assertiveness
Planning ahead
Having a supportive friend and family
Not putting up with it. Knowing which battles to fight, which
comments to let go.

Key messages to remember from the session were:

We are sharing this experience
Its been a relief to share it
We are not the only ones
We want to live a normal life
We are not going to be defeated
We want to be ‘in’ it.

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Monday, December 5, 2016

MEBO TMAU Test Program United States only

Click on MEBO Map to see where TMAU testing is in the world 
Please notify of other sites to maria@meboresearch.org

It is with deep regret that I announce that MEBO will not be shipping the TMAU test international for the time being for the following reasons.
  1. The cost of the test plus round trip shipping is within the $300+ to $400+/USD, which is too high for some countries who have a low currency exchange against the US dollar. Most often, the shipping cost is the same as the test itself ($150/USD) or significantly higher than the test cost.

  2. Many countries like China, Australia, Brazil, Singapore, and others do not allow either payments made to a charity of a foreign country or do not allow the kit to enter their country, or do not allow the test to be performed unless a medical doctor in their country to prescribe the test.

  3. Due to numerous reasons, Custom Agencies may delay the 2 day sample shipment to enter the United States, thus resulting in the samples being too long at room temperature or higher, and thus, may give spurious results.  After paying the much higher rate than the US sufferers have to pay, there is a significant risk that the samples would be damaged in transit to the United States, and this is unacceptable.


I was my intention to provide TMAU testing to all sufferers around the world, but very few indeed have actually been able to do the test because of the reasons stated above. Thankfully, more and more labs around the world are offering the genetic test, though very few other than the United Kingdom that I know of, are offering the urine test.

The genetic test obviously checks for Primary TMAU, a genetic mutation resulting in a deficient FMO3 metabolic enzyme function, thus allowing for high levels of the odorous trimethylamine (TMA) chemical in the blood. That I am aware of, only MEBO and the UK Sheffield lab offers the urine test that also tests for Secondary TMAU, which is the result of an overproduction of TMA in gut bacteria that overloads a fully functional FMO3 enzyme, thus allowing for high levels of TMA in the blood. Both Primary and Secondary TMAU have high TMA body odor symptoms, though with different causes.


María

María de la Torre
Founder and Executive Director

A Public Charity
www.meboresearch.org
www.brasil.meboresearch.org
maria.delatorre@meboresearch.org
MEBO's Blog (English)
El Blog de MEBO (español)
MEBO Brasil - Blog (Portuguese)



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Sunday, December 4, 2016

References on TMAU in English and Spanish


Just Yesterday a sufferer in Mexico said she has to do a thesis for her Master's in Science degree, and wants to do it on TMAU. She asked me for information. I really believe that MEBO should support sufferers who are students, especially when they want to focus their studies on the medical causes and treatment of breath and body odor conditions. So, I spent most of the day researching college level info and giving her experts' information so that she may contact them, if she wants.

I think I'll share the info with this group as well. The first part is in Spanish, since she is doing her thesis in Spanish, and the 2nd part is in English.

EN ESPAÑOL:

Organización de apopyo en América Latina y España
http://olorcorporalyhalitosis.blogspot.com/search/label/organizaciones%20de%20apoyo%20en%20Am%C3%A9rica%20Latina%20y%20Espa%C3%B1a

Entrevistas con expertos:
http://olorcorporalyhalitosis.blogspot.com/search/label/Entrevista%20con%20expertos

Webinar sobre la TMAU por la Dra. Mercedes Serrano
http://olorcorporalyhalitosis.blogspot.com/2013/11/6-webinar-sobre-la-trimetilaminuria-en.html

Resumen de la Trimetilaminuria y su protocolo
http://olorcorporalyhalitosis.blogspot.com/2016/09/enlaces-informacion-sobre-la.html

Guia Metabólica
http://www.guiametabolica.org/enfermedad/trimetilaminuria

Trimetilaminuria congénita, adquirida y transitoria
http://olorcorporalyhalitosis.blogspot.com/2014/04/trimetilaminuria-congenita-adquirida-y.html

Diagnóstico de trimetilaminuria en Madrid y Barcelona
http://olorcorporalyhalitosis.blogspot.com/2012/09/diagnosticar-trimetilaminuria-en-madrid_22.html

Artículo Federación Española de Enfermedades Raras (FEDER)
http://olorcorporalyhalitosis.blogspot.com/search/label/FEDER (Si recuerdo bien, el artículo dice equivocadamente que se puede comer la yema de huevo pero no la clara, y es lo opuesto. La yema es muy alta en colina.)

Pros y Contras de la prueba de TMAU
http://olorcorporalyhalitosis.blogspot.com/search/label/PROS%20Y%20CONTRAS%20prueba%20TMAU

Resumen del protocolo de reduccion de Olor por TMAU
http://olorcorporalyhalitosis.blogspot.com/2014/03/resumen-del-protocolo-de-reduccion-de.html

Sobre la Trimetilaminuria Primaria y Secundaria
http://olorcorporalyhalitosis.blogspot.com/2010/12/sobre-la-trimetilaminuria-primaria-y.html

Consecuencias Psicosociales del olor corporal incontrolable
http://olorcorporalyhalitosis.blogspot.com/2010/12/las-consecuencias-psicosociales-del.html

Supresión de la producción intestinal como tratamiento para la TMAU
http://olorcorporalyhalitosis.blogspot.com/2009/06/supresion-de-la-produccion-intestinal.html




IN ENGLISH:


http://www.orpha.net/consor/cgi-bin/Disease_Search_Simple.php?lng=EN&type_list=Other_Websites&LnkId=24238&Typ=Pat&from=rightMenu


INTERVIEWS WITH EXPERTS:


http://www.meboblog.com/search/label/interview%20with%20experts

http://tmau.org.uk/index.php/joomlaorg/72-tmau-interview-with-n-manning

http://tmau.org.uk/index.php/joomlaorg/71-tmau-interview-with-dr-lachmann


POWERPOINT PRESENTATIONS:


http://www.meboblog.com/2011/04/professor-elizabeth-shephard-tmaufmo3.html

http://www.meboblog.com/2012/06/dr-shephards-miami-beach-presentation.html

http://www.meboblog.com/2011/06/fmo3-genetics-lesson-part-2-dna-rna-and.html


PROFESSIONAL PAPERS:


http://www.meboblog.com/2011/01/new-fmo-research-paper-from-phillips.html

http://www.meboblog.com/2009/07/fmo3-paper-july-2009-expression-and.html

http://www.meboblog.com/2009/07/new-fmo3-paper-norwegian-family-with.html


TRIMETHYLAMINURIA REREFENCES:



Utility gene card on Trimethylaminuria
http://www.meboblog.com/2011/12/new-clinical-utility-gene-card-on.html

FMO3 coding sequence
http://www.meboblog.com/2011/10/fmo3-coding-sequence-for-wild-type.html#more

TMAU paper by New Zealand test lab
http://www.meboblog.com/2011/04/new-tmau-paper-by-new-zealand-test-lab.html

Carnatine, not just choline to be avoided in TMAU diet
http://www.meboblog.com/2010/08/carnitine-not-just-choline-to-be.html


WEBINARS



http://www.meboblog.com/search/label/webinars


RESEARCH GRANT:


http://gtr.rcuk.ac.uk/project/772B5BB8-C185-455B-9AE2-C4BC7F8369DF

http://www.meboblog.com/2013/06/details-of-uk-medical-research-council.html

http://www.meboblog.com/search/label/Research%20Award

http://www.meboblog.com/2012/08/update-on-work-of-nord-research-at.html

http://www.meboblog.com/2009/02/2007-paper-monell-senses-center.html

Links to discussion of liver damage due to decrease of choline in the diet.
http://m.livescience.com/53138-targeting-microbes-could-lower-heart-disease-risk.html

http://systemicbodyodor.blogspot.com/2016/01/does-low-choline-cause-fatty-liver.html?m=1

http://www.ncbi.nlm.nih.gov/pubmed/26773011

Links to discussion of the effects of DMB on choline,  l-carnitine, and lecithin ingestion –> TMA production by gut bacteria –> TMAO production by FMO3 metabolic enzyme in the liver.

http://mobile.buffalonews.com/?articleRedirect=1&url=http%3A%2F%2Fwww.buffalonews.com%2Fcolumns%2Fdrs-oz-and-roizen%2Fdrs-oz-and-roizen-dodge-this-major-heart-risk-20160116

These articles to be saying is that experts' research indicates that taking DMB, especially with a low choline diet, decreases TMA levels and increases choline levels in the body, and thus may not cause nonalcoholic fatty liver disease. Instead of decreasing the amount of choline that goes to the liver, it helps protect the choline from the gut bacteria would have normally consumed to produce odorous TMA. DMB actually prevents the bacteria from consuming choline, so the choline goes to the bloodstream to the liver. DMB also prevents the bacteria from producing TMA. It's a win-win situation, but only for sufferers who do have TMA producing bacteria in the gut.

For sufferers who don't have TMA producing bacteria in the gut, DMB won't really have much effect. These sufferers really need for the MEBO Metabolomic Profiling research project to give more answers on other causes of odor conditions. However, a very strict low choline diet is definitely a danger to TMAU sufferers and non-TMAU sufferers for developing nonalcoholic fatty liver. We do need to keep in mind that there may also be other causes of nonalcoholic fatty liver, such as medication and diet.

That’s exactly what its implying, especially vital for TMAU sufferers with bacterial overgrowth problems, the vast majority of the choline being converted to TMA not leaving much at all by the time it gets to your liver leaving very little choline to decongest the fat in our livers, along with our reduced choline intake its quite worrying what impacts this has on our livers.

That along with the mental health benefits from choline which I’ve always been worried about, too many TMAU sufferers are subjected to mental health problems because of the nature of the illness, the reduced choline levels very much amplify this. See here:


Treating Depression and Anxiety Through Choline Supplements


http://www.nootropicsinfo.com/anxiety/treating-depression-and-anxiety-through-choline-supplements/


Information on Choline, as an essential nutrient.


http://lpi.oregonstate.edu/mic/other-nutrients/choline

Sufferers of TMAU need to go on a low choline diet in order to control their odor symptoms. However, it can be very dangerous to one's health because choline is an essential nutrietn. Low choline diet can cause non-alcoholic fatty liver and increased anxiety and depression. It causes severe neurological abnormal development in fetuses.

María

María de la Torre
Founder and Executive Director

A Public Charity
www.meboresearch.org
www.brasil.meboresearch.org
maria.delatorre@meboresearch.org
MEBO's Blog (English)
El Blog de MEBO (español)
MEBO Brasil - Blog (Portuguese)



SUPPORT THE MEBO MISSION: Click Amazon button at right sidebar of this blog when shopping online for the holidays
at no extra cost to you.
MEBO gets small commission from Amazon.


Please use your credit card to make your donation to MEBO.


Subscribe for latest posts : Enter your email address:

Delivered by FeedBurner


A EURORDIS and NORD Member Organization