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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU UK end total:262
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TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


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Analysis start in/before Nov
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Sunday, October 14, 2012

pilot study : effect of (E, E)-2, 4-Undecadienal in deodorizing trimethylmaine

effect of (E, E)-2, 4-Undecadienal on TMA odor
Pilot Study 2013 (Presumably this copy is ahead of official publication)
Effect of (E, E)-2, 4-Undecadienal on the Offensive Odour of Trimethylamine
Pankaj Garg, Kevin Carpenter, Shanley Chong, John Christodoulou AM

In this study, the object was to see the effect that  (E, E)-2, 4-Undecadienal had on the Offensive Odour of Trimethylamine. The abstract says that  (E, E)-2, 4-Undecadienal is known to have a deodorizing effect on the odor from 'chitlins' (cooked porcine intestines). It was tested in a solution of trimethylamine and volunteers were asked to comment on the effect on the trimethylamine odor.

It is interesting to note that out of 12 people, one person could not detect the odor of trimethylamine at all. The abstract finishes by saying the mechanism for this deodorizing effect is not yet known.

The abstract can be seen here :
A Pilot Study of the Effect of (E, E)-2, 4-Undecadienal on the Offensive Odour of Trimethylamine
related links Identification of (E,E)-2,4-Undecadienal from Coriander (Coriandrum sativum L.) as a Highly Effective Deodorant Compound against the Offensive Odor of Porcine Large Intestine


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NORD Member Organization

4 comments:

Anonymous said...

Can we buy the compound ourselves?

Oct 15, 2012, 5:15:00 AM
blogcontributor2 said...

I don't think so yet. I think it can be bought to specialists via specialist chemical companies but not to the public. I'm sure in the future it will likely be packaged as a food grade supplement for human consumption same as chlorophyll or charcoal.

Oct 15, 2012, 12:52:00 PM
Anonymous said...

I think cilantro leaves contain this chemical, and you can find them in the produce department of a grocery store. Search on Google for articles about cilantro erasing the odor of boiling chitlins. Also see the Yahoo message board on TMAU for more discussion.

Oct 15, 2012, 9:25:00 PM
blogcontributor2 said...

Yes it is a chemical found in cilantro/coriander leaves. I suppose the original study was to find what was it in cilantro that most had the deodorizing effect.

Oct 16, 2012, 7:16:00 AM
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