P&G TMA inhibitor supplement : 1st sign of patent

TRIMETHYLAMINE INHIBITOR THERAPY

The community has been aware since around August 2015 that Procter & Gamble are working on a supplement which will be a trimethylamine inhibitor in the gut.

For the first time, we can see the patent publicly (published on June 1 2017).
Here is the patent via the freepatentsonline website :
PDF version
Via the site (without images) 
P&G Press Release on product (Aug 2015)

The patent is titled :
COMPOUNDS AND METHODS FOR INHIBITING PRODUCTION OF TRIMETHYLAMINE

It looks like it was filed on Dec 1 2016.

The 'skinny' on this is :
It will be over-the-counter (no prescription needed)
It is being created due to a 2011 paper by Dr Hazen et al at Cleveland Clinic which implicated TMA-oxide as a causal factor in heart disease development.
Dr Hazen et al are working on the supplement under licence to Procter & Gamble.

For now we are digesting the information.
More posts will follow on the subject.
Comments and interpretations are welcome.

Probably the product still has a long way to be on sale.    

The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I)

The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.

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