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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Thursday, June 8, 2017

P&G TMA inhibitor supplement : 1st sign of patent


The community has been aware since around August 2015 that Procter & Gamble are working on a supplement which will be a trimethylamine inhibitor in the gut.

For the first time, we can see the patent publicly (published on June 1 2017).
Here is the patent via the freepatentsonline website :
PDF version
Via the site (without images) 
P&G Press Release on product (Aug 2015)

The patent is titled :

It looks like it was filed on Dec 1 2016.

The 'skinny' on this is :
It will be over-the-counter (no prescription needed)
It is being created due to a 2011 paper by Dr Hazen et al at Cleveland Clinic which implicated TMA-oxide as a causal factor in heart disease development.
Dr Hazen et al are working on the supplement under licence to Procter & Gamble.

For now we are digesting the information.
More posts will follow on the subject.
Comments and interpretations are welcome.

Probably the product still has a long way to be on sale.    

The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I)

The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.

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Anonymous said...

This is such a good news for so many people including me ... thanks for sharing and keeping the hope alive ..

Jun 9, 2017, 8:00:00 AM
Anonymous said...

So happy to hear this how long do u think it will be to go on sale

Jun 29, 2017, 5:37:00 PM
Unknown said...

I am 55 and have suffered with TMAU all my life, this news gives me hope and if the inhibitor really does the job then I will have a whole new lease on life. I cannot wait!

Jan 14, 2018, 11:23:00 AM
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