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Monday, June 16, 2008

Could leaky gut be a factor in Fecal Body Odor ?

It's unknown if something like 'leaky gut' (gut permeability) could be a factor in something like, for instance 'fecal body odor'. Research into 'leaky gut' in general seems lacking, but sometimes interesting (unrelated) research is published. For instance, this 1999 paper about only alcoholics with 'leaky gut' having cirrhosis ...
Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage.

Two functions of the gut wall are to physically act as a sieve (to not allow molecules too big to be absorbed into the portal vein), and also to absorb suitable sized molecules in a controlled manner (often actively, as well as passively).

In the case of 'leaky gut', it is proposed that for some reason the junctions of the cells are not properly joined, and molecules too large are then allowed through the gaps into the portal vein.

Ironically, if the 'absorption' system through the gut wall cells is also interfered with for some reason, for example irritation, someone can then have potential 'malabsorption' as well as leaky gut.

The current common test for leaky gut usually tests both for 'leaky gut' and also malabsorption, using 2 sugars, lactulose (a large molecule), and mannitol (a small molecule). The other alternative common test is the polyethylene glycol (PEG) test

some leaky gut explanations :

from an Autism research unit at Sunderland University : http://osiris.sunderland.ac.uk/autism/gut.htm
Leo Galland article : http://www.mdheal.org/leakygut.htm
Dr Myhill article : http://www.drmyhill.co.uk/article.cfm?id=47
http://en.wikipedia.org/wiki/Leaky_gut_syndrome
http://altmedicine.about.com/od/healthconditionsdisease/a/TestLeakyGut.htm

(example) pubmed search result

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