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Monday, October 6, 2008

Detoxigenomics dna test by Genova Diagnostic: tests many detox enzymes but not FMO3

Note: this is posted only to make sufferers aware of options. It is not posted as advice or to be regarded as wholly accurate.
One main point of investigation for many bloodborne body odor and halitosis cases is likely to be the genetic make-up and a weakness in one or more cell enzymes, particularly the detox enzymes. FMO3 enzyme seems the most likely first candidate to check out, but since something like 'fecal body odor' is not accepted by the medical system, at this point nothing can be ruled in or out.

Gene testing is a very new science. You could say it's only been maturing the last decade or so. The full FMO3 gene coding was only discovered around 10 years ago. In the future, your health maintenance will likely be based around your genetic make-up (we all usually have weaknesses of some sort), but for the moment the medical experts are likely to pour scorn on genetic tests available to the public (they seem to do this with regards many sensible innovations until they can no longer sustain their position, or are instructed.) Apart from the Roche 'Amplichip test', since this is a big pharmaceutical company who has salesmen and adverts, and is part of the mutual self-preserving system (Not meaning to be cynical. This is an honest assessment). It has FDA clearance.

One such test available is Genovas Detoxigenomic genetic profile test, which looks at the main detox enzymes for known 'weak/mutant' genes. It includes most of the enzymes mentioned often on this blog, but sadly not the FMO family, since even they likely regard this as a less important 'ubiquitous' enyme at the moment. The Chief Medical Officer of Genova diagnostics is Dr Patrick Hanaway. The test itself seems a reasonable price. at around $450. You cannot buy direct but there will be sellers on the net. Whilst there is no doubt they try their best, it must be assumed that currently there is not enough known about mutants/SNPs for them to know every mutant/SNP. Genova is a reputable company respected in Functional Medicine.

DNA test. enzyme type tested

detox phase 1 : cyp 1a1 ,cyp 2a6, cyp 2e1, cyp 1c19, cyp 1b1, cyp 2d6, cyp 2c9, cyp 3a4
detox phase 2: methylation, acetylation, glutathione (3 out of 6 of the main phase 2)

protecting enxyme (protects the detox enzymes from oxidative damage) : superoxide dismutase

At the moment, this test (or a similar one) along with a FMO DNA test seems to be a best way to cover all the main detox enzymes genetically in a bloodborne body odor or halitsosis sufferer. Since DNA testing is at a relatively early stage, it's likely that many more mutant/weak versions of the chomosomes are likely to be found, but it seems the best option currently. Genetic tests do not tell you at what % your enzyme function is working at, they only tell you if you have 'suspect' DNA candidates.

It should also be remembered that just because you have a weakness, it doesn't follow that you are 'doomed'. It's unknown how much the 'environmental' aspect of bloodborne odors plays a part, but it is likely to be a major factor (perhaps even the main factor.) Also, some develop bloodborne odors way beyond the puberty years, and may be advised by an expert not to bother testing for primary TMAU (even though some go on to do so anyway and find themselves positive for primary TMAU). This suggests envirnomental factors being an unknown factor. For instance it may be that the toxic gut load is a huge factor in fecal body odor. Possibly FMO3 is quite highly present in the gut (as well as the liver), and so normal people have 2 hurdles for those toxins, whereas someone with low FMO3 likely may always have difficulty keeping their gut flora in control and have to use maintenance measures. This is not yet known.

This is posted to help people aware of the options. Perhaps as a group we will someday have enough data to see a pattern in metabolic body odor and halitosis and disvover the true picture ourselves.


Reference:
Genova diagnostics Detoxigenomics test
Main Detoxigenomics testing inormation (PDF format)
Sample report (PDF format)

Example of a seller. Directlabs may also sell. A blood sample is needed.
http://www.centerfornaturalmedicine.com/newsletters/Genes.htm

DetoxiGenomics looks at liver detoxification paths and enzymes that may be lacking for efficient coping with toxins in the environment and some drugs. This could relate to risk for some cancers, tendency to chronic fatigue, fibromyalgia and poor ability to withstand many drugs and chemicals. $449.00

Roche Amplichip test (FDA approved). Given as an example of how mainstream medicine is moving this way.
Mayo clinic page on CYP450 genotype testing

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