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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Thursday, June 26, 2008

Hepatic portal vein : an explanation

This is an attempt to explain how things absorbed from the gut end up in the hepatic portal vein awaiting assessment by the liver, before then entering the main circulation.

The body will do all it can to keep the main circulating blood as clean as possible. With regards to the things absorbed from the gut, it has 2 main ways of making sure the absorbed material is as clean as possible before entering the main circulation: The gut wall barrier, and the hepatic portal vein 'waiting room', which is where all the absorbed material ends up and is then procesed by the liver, usually by the xenobiotic enzymes altering them

1. The gut wall barrier: Simply stops molecules too big from being absorbed into the portal vein when working correctly.
2. The portal vein: You can think of it as a waiting line for a screening check by the liver, before entrance to the main circulation. These molecules will (usually) be absorbable size, and for the most part the xenobiotic enzymes of the liver will then alter (neutralizing) the 'baddies' and possibly activate the 'goodies' (if need be). Once assessed and altered by the liver, it then enters the main bloodstream.

It's probably not as simple as that, but in general that's probably what mostly happens.

contents of the gut >>
gut wall keeps molecules too big from being absorbed (this is where leaky gut is a concern) >>
then enters the hepatic portal vein awaiting assessment by the liver>>
then the liver alters/neutralizes/activates the molecules >>
only then enters the main circulation


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