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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Sunday, June 15, 2008

What bloodborne body odor and halitosis means

According to the Merriam-Webster’s Online Dictionary, borne means “to transport or transmit by - used in combination 'soilborne' 'airborne" [1], and the Merriam-Webster’s Medical Dictionary defines blood-borne as “carried or transmitted by the blood”. [2] This could be anything from blood-borne nutrients, blood-borne hormones, a blood-borne disease, etc. Although serious contagious diseases can be blood-borne, most everything that is blood-borne is not a contagious pathogen, and most people don’t have blood-borne contagious pathogens.

Most certainly, metabolic bloodborne body odor/halitosis has nothing to do with contagious/bloodborne pathogens. When we refer to bloodborne body odor, we refer to the abnormal levels of odorous chemicals allowed (mainly) by the liver to enter the main circulation, and the subsequent toxins this imbalance produces that are carried in the main circulating blood and excreted unchanged through the body’s cleansing organs, such as the kidneys, skin, breath (via the lungs), etc. This results in body odor and/or halitosis that stems from the internal system.

The odorous chemicals present in the bloodstream can be the product of a low amount of the metabolic enzyme(s) that otherwise would normally neutralize the odorous chemicals before entering the bloodstream (or in some cases, chemicals produced internally e.g. hormones). Another cause could be simply because the enzyme(s) is completely overloaded (saturated) by the load it has to deal with. For instance if you eat garlic and smell, this is the garlic chemicals overloading an enzyme(s) that is supposed to neutralize the chemicals before they enter the main circulation. And of course, it could also be caused by both.

This concept is mentioned by Dr. Stephen Mitchell, Biological Chemistry, Biomedical Sciences, Faculty of Medicine, Imperial College London, in his article, SC Mitchell (2005) Trimethylaminuria (fish-odour syndrome) and oral malodour, in which he states,

A small but important percentage of oral malodour cases have an extra-oral aetiology and certain of these fall into the category of ‘blood-borne halitosis’. Odoriferous substances generated within the body and transported to the lungs via the circulatory system may, if sufficiently volatile, leave with the exhaled air and impart a foetid odour to the breath. [3]


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