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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, July 25, 2008


Very little scientific research seems to have been devoted to why and what makes asparagus consumption result in the person having smelly urine in some cases, and not in other people's cases. Of the little research regarding asparagusuria found in Pubmed, the points made are contradictory, but for now it may be prudent to go with the conclusions based mostly on research by Mitchell and Waring, since they have done the most, but also take the few other papers into consideration. The observations were :

1. The smelly urine is a genetic autosomal dominant rule. Meaning they suggest you only need one 'copy' of the responsible gene for the condition to occur. This is the opposite of what the medical books generally regard TMAU (autosomal recessive. Meaning you need 2 bad copies). If it turned out 'bloodborne odors' was autosomal dominant, it would bring in a lot more people into the equation of having bloodborne body odor. It does seem that one or more TMAU experts probably do now feel that 'transient' TMAU is likely to be autosomal dominant, given some of the papers on pubmed, although it doesn't seem to be a current official 'rule'.

2. About 40% (in one study) were regarded as being unable to smell the urine whether it was theirs or anyone elses (non-perceivers)

3. there are 3 possible outcomes:
no smell from the urine (the smelly metabolites are not there - non-excretors)
the urine smells (excretors)(in about 8% of the UK Caucasian population it is super-smelly, since they have 2 copies of the excretor gene - homozygous)
the urine smells but the sufferer can't smell it (excretors but non-perceivers).
However, none of the above outcomes is 'official', since the few papers give contradictory outcomes.

There is the possibility that the asparagusuria urine test could be a cheap test for potential bloodborne body odor cases, but this must currently be considered unlikely. Possibly the bloodborne BO cases would be the super-smelly urine cases, with them also being unable to smell their own urine, same as what seems to happen in most bloodborne BO cases. An expert suggested that one possibility is that those who excrete super-smelly urine may be 'non-perceivers' because their smell receptors could be already saturated.

Overall, nothing can be deduced from this post in connection to bloodborne body odor/halitosis, and it is posted only as something to think about.

pubmed asparagus odor urine search
Mitchells last paper (2001) on Asparagusuria
Interesting comments on

Try the asparagus urine test.
Poll : Did your urine smell ? click below

note : the inabilty to smell asparagus urine is not taken into account in the polls


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