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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Sunday, July 27, 2008

Handbook of Drug Metabolism - Google Book Search

This is a respected book on the drug metabolizing enzymes (1999). The chapter on Flavin Mono Oxygenase enzymes is written by the well known respected FMO expert, Dr John Cashman of HBRI. Given that little research goes on with regards FMO, but more research has been done recently, it is unclear how up to date the chapter will be.

Of interest is where Dr Cashman says lowered FMO function is likely to be associated with other metabolic conditions since this doesn't seem to be the general impression given from medical websites/books. Google books has pages missing, but you can get a general sense of the enzyme from the chapter.

Handbook of Drug Metabolism (1999)
Edited by Thomas F. Woolf

Finally, the role of FMO in human disease conditions is certain to be studied in increasing detail in the future. The abrogation of human FMO3 has been associated with trimethylaminuria, but it is likely the variant forms of FMO are associated with other abnormal metabolic conditions because trimethylaminuria patients appear to suffer from a number of other disease states as well. With the emergence of new and sensitive selective molecular probe of human FMO, it is possible that a role of FMO in human disease conditions will be clarified... - the chapter on FMO enzymes from the Handbook of Drug Metabolism


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