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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
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BO Sufferers Podcasts

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Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Sunday, July 27, 2008

Handbook of Drug Metabolism - Google Book Search

This is a respected book on the drug metabolizing enzymes (1999). The chapter on Flavin Mono Oxygenase enzymes is written by the well known respected FMO expert, Dr John Cashman of HBRI. Given that little research goes on with regards FMO, but more research has been done recently, it is unclear how up to date the chapter will be.

Of interest is where Dr Cashman says lowered FMO function is likely to be associated with other metabolic conditions since this doesn't seem to be the general impression given from medical websites/books. Google books has pages missing, but you can get a general sense of the enzyme from the chapter.

Handbook of Drug Metabolism (1999)
Edited by Thomas F. Woolf

Finally, the role of FMO in human disease conditions is certain to be studied in increasing detail in the future. The abrogation of human FMO3 has been associated with trimethylaminuria, but it is likely the variant forms of FMO are associated with other abnormal metabolic conditions because trimethylaminuria patients appear to suffer from a number of other disease states as well. With the emergence of new and sensitive selective molecular probe of human FMO, it is possible that a role of FMO in human disease conditions will be clarified...

http://books.google.com - the chapter on FMO enzymes from the Handbook of Drug Metabolism

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