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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Thursday, August 7, 2008

fecal body odor : one hypothesis : substrate overload?

The following is only posted to promote discussion

Substrates is the name for compounds that make natural 'fodder' for our detoxifying enzymes. For instance trimethylamine is a natural substrate for FMO enzymes, which the enzyme will oxidize into non-smelly trimethylamine-n-oxide.

In the UK, if someone has more TMA in their urine than the tester expected, going by a set of test standards presumably decided upon by one or more testers in the UK, they are saying that the enzyme is saturated by too much TMA substrate. Consequently, it is diagnosed as secondary TMAU (example link, 2001: Diagnosis ). It is unclear if 'secondary TMAU' is tested elsewhere.

If someone smells of garlic or curry through their skin pores, you can say the enzymes involved in breaking down those compounds have been temporarily saturated. (anecdotal example 1, anecdotal example 2 )

In the case of fecal body odor, there must be a possibility that for some reason the enzymes involved are saturated by too much substrates from the gut produced by gut microbes. If this was so, you would have to assume this type of FBO must be to do with some type of dysbiosis, whether it was bacteria, parasites, or candida. However, it is significant to keep in mind that the vast majority of people with dysbiosis-type problems do not have fecal body odor. So it looks to be a 'syndrome', perhaps with a few factors being necessary. Or else some unique dysbiosis pattern.

Or perhaps a certain type of bacteria is overgrown and inhibiting one or more detox enzyme (most detox enzymes can be inhibited. FMO was regarded as being 'ininhibitable' (and probably is still taught as this in medical textbooks), but has been shown to be inhibited by brussel sprout consumption (pubmed paper ). At the moment there is no awareness of this problem and no research ongoing.

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