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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Thursday, August 7, 2008

fecal body odor : one hypothesis : substrate overload?

The following is only posted to promote discussion

Substrates is the name for compounds that make natural 'fodder' for our detoxifying enzymes. For instance trimethylamine is a natural substrate for FMO enzymes, which the enzyme will oxidize into non-smelly trimethylamine-n-oxide.

In the UK, if someone has more TMA in their urine than the tester expected, going by a set of test standards presumably decided upon by one or more testers in the UK, they are saying that the enzyme is saturated by too much TMA substrate. Consequently, it is diagnosed as secondary TMAU (example link, 2001: Diagnosis ). It is unclear if 'secondary TMAU' is tested elsewhere.

If someone smells of garlic or curry through their skin pores, you can say the enzymes involved in breaking down those compounds have been temporarily saturated. (anecdotal example 1, anecdotal example 2 )

In the case of fecal body odor, there must be a possibility that for some reason the enzymes involved are saturated by too much substrates from the gut produced by gut microbes. If this was so, you would have to assume this type of FBO must be to do with some type of dysbiosis, whether it was bacteria, parasites, or candida. However, it is significant to keep in mind that the vast majority of people with dysbiosis-type problems do not have fecal body odor. So it looks to be a 'syndrome', perhaps with a few factors being necessary. Or else some unique dysbiosis pattern.

Or perhaps a certain type of bacteria is overgrown and inhibiting one or more detox enzyme (most detox enzymes can be inhibited. FMO was regarded as being 'ininhibitable' (and probably is still taught as this in medical textbooks), but has been shown to be inhibited by brussel sprout consumption (pubmed paper ). At the moment there is no awareness of this problem and no research ongoing.


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