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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
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BO Sufferers Podcasts

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Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
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NORD Member Organization
See RareConnect
rareconnect.org TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

https://www.meboblog.com/2023/01/denver-tmau-test-survey-tbc-who-it-is.html

Thursday, August 21, 2008

News article: Fruit Juices can inhibit cell enzymes

Following on from the biochemical individuality post, this was announced yesterday at the 236th National Meeting of the American Chemical Society by David G. Bailey, Ph.D. of the University of Western Ontario in London, Ontario; the researcher who first discovered grapefruit greatly inhibits CYP3A4 activity, in 1989. In this case he is saying a few fruit juices can affect 2 enzymes; one that helps with absorption from the small intestine (meaning the drug wouldn't be absorbed as much as expected), and the other (CYP3A4) which clears the drug from the blood once it has been absorbed (meaning it will take far longer than expected to clear from the bloodstream). The main point is that he feels many things will affect these enzymes. In the diet, often the strongest inducers/inhibitors would be things like herbs, spices, fruit and vegetables. It is normal for things to induce/inhibit most of the detox enzymes, often favorably, but if there is a shortage/vulnerability/overload of any detox enzyme, it is more likely to have a bad effect.

Note: The CYP450 enzyme mentioned relates only to intestinal CYP3A4. It is not currently thought to affect hepatic CYP3A4, which is where CYP3A4 is mostly situated.

http://www.sciencedaily.com/releases/2008/08/080819160050.htm


...By contrast, drugs whose levels are boosted in the presence of grapefruit juice appear to block an important drug metabolizing enzyme, called CYP3A4, that normally breaks down drugs.

"This is just the tip of the iceberg," Bailey says. "I'm sure we'll find more and more drugs that are affected this way."

To date, grapefruit, orange and apple juices have been shown to lower the absorption of etoposide, an anticancer agent; certain beta blockers (atenolol, celiprolol, talinolol) used to treat high blood pressure and prevent heart attacks; cyclosporine, a drug taken to prevent rejection of transplanted organs; and certain antibiotics (ciprofloxacin, levofloxacin, itraconazole). But additional drugs are likely to be added to the list as physicians become more aware of this drug-lowering interaction, Bailey says...

examples:
http://www.ncbi.nlm.nih.gov/pubmed/11489435
http://www.ncbi.nlm.nih.gov/pubmed/14641551
http://www.greenjournal.org/cgi/content/full/105/2/429
http://www.globalrph.com/gfruit.htm

keywords/concepts
inhibition/induction
substrate
CYP3A4 (The 'busiest' of the CYP450 family of enzymes)
intestinal CYP3A4, hepatic CYP3A4

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