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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Sunday, August 10, 2008

Trimethylaminuria Pubmed paper 1997: A pharmacogenetic study of trimethylaminuria in Orientals

A study of the metabolism of trimethylamine was carried out in 103 healthy Thai volunteers
TMA-N-O/TMA ratio : trimemthylamine-n-oxide (good)/trimethylamine (smelly) ratio
84%: may be a mild 'fail' today.
TMA capsule test (600mg): Another TMAU paper suggests this as a urine 'carrier' test

This is posted as an anecdotal case. It is of interest partly because it is a new name carrying out the paper. He didn't test the normal volunteers with a challenge test and found their TMA-N-O/TMA ratio to be about 84%-100%. Today in a few (of the few) TMAU test labs, around 84% may be deemed borderline or even a very mild case (bearing in mind also it wasn't a challenge test). He then tested 5 'known' TMAU cases and found them to be around 8-35% (very low), and then used a TMA capsule challenge test (elsewhere TMA capsules are used as a 'carrier' challenge test) and found them to be even lower %s. With DNA testing, he found the 5 to be classic 'TMAU autosomal recessive' cases.

Thithapandha A.

Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
A study of the metabolism of trimethylamine was carried out in 103 healthy Thai volunteers (70 men and 33 women) and it was found that under normal dietary conditions 84-100% of trimethylamine was excreted in the urine in its N-oxide form. Five propositi living in different parts of the country were identified as having deficiency in the N-oxidation of this tertiary amine, because they excreted only 8-35% of this chemical as trimethylamine N-oxide...


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