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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country

MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Sunday, August 10, 2008

Trimethylaminuria Pubmed paper 1997: A pharmacogenetic study of trimethylaminuria in Orientals

A study of the metabolism of trimethylamine was carried out in 103 healthy Thai volunteers
TMA-N-O/TMA ratio : trimemthylamine-n-oxide (good)/trimethylamine (smelly) ratio
84%: may be a mild 'fail' today.
TMA capsule test (600mg): Another TMAU paper suggests this as a urine 'carrier' test

This is posted as an anecdotal case. It is of interest partly because it is a new name carrying out the paper. He didn't test the normal volunteers with a challenge test and found their TMA-N-O/TMA ratio to be about 84%-100%. Today in a few (of the few) TMAU test labs, around 84% may be deemed borderline or even a very mild case (bearing in mind also it wasn't a challenge test). He then tested 5 'known' TMAU cases and found them to be around 8-35% (very low), and then used a TMA capsule challenge test (elsewhere TMA capsules are used as a 'carrier' challenge test) and found them to be even lower %s. With DNA testing, he found the 5 to be classic 'TMAU autosomal recessive' cases.

Thithapandha A.

Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
A study of the metabolism of trimethylamine was carried out in 103 healthy Thai volunteers (70 men and 33 women) and it was found that under normal dietary conditions 84-100% of trimethylamine was excreted in the urine in its N-oxide form. Five propositi living in different parts of the country were identified as having deficiency in the N-oxidation of this tertiary amine, because they excreted only 8-35% of this chemical as trimethylamine N-oxide...


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