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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Wednesday, October 8, 2008

Pubmed paper: FMO (flavin-containing monooxygenase enzyme) induced in mice by aryl hydrocarbon.

Pubmed paper September 2008

This is a paper published recently by researchers at the University of Toronto, where mice were shown to have FMO3 induced by a xenobiotic (aryl hydrocarbon). It's unclear if this has any significance to poor FMO3 function in humans, but does seem to put a few small dents in what students are taught at medical school, that FMO3 enzyme is neither inducible nor inhibitable (although this was already disproven when indoles were shown to inhibit the enzyme in 1999). They were testing the detox enzymes with aryl hydrocarbon in 2006 and discovered FMO was inducible, so it looks like they concentrated on FMO in particular this time.

Probably most/all FMO/TMAU experts will regard FMO as uninducible.

The lead researcher was asked about the finding in an email, and replied that he doesn't think it has any promise to helping TMAU currently. He is about to retire and his lab does not research metabolism directly, so it looks like that line of research from that group may have run it's course. How much impact this has on understanding FMO is unkown.

The full paper is available free in PDF format on this site: Drug Metabolism and Disposition

It is not known whether TCDD can induce hepatic FMO3 in humans. We aligned the mouse AHR-associated region with human and rat genomes by a BLAT analysis (Kent, 2002); see Suppl Fig. 5). The mouse AHR-associated region showed minimal overlap with genomic sequences in human (26 of 78 base-pairs aligning) or in rat (20 of 78 base-pairs aligning). Further, the aligned regions are on separate chromosomes from the FMO3 gene in each species. Taken together these results suggest that the AHR-binding-element is part of a mouse-specific regulatory module and, at present, it cannot be inferred from promoter analysis in silico whether human FMO3 is likely to be inducible by AHR agonists.


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