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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Wednesday, November 26, 2008

1996 trimethylaminuria paper : What % of people would fail the trimethylaminuria urine test in a sample population ?

1996 pubmed paper: 3.8% fail the 90% trimethylaminuria urine test in a British sample of 421 people (Mitchell, Smith, Zhang - Imprerial College London)

Since there is no interest from the medical system in metabolic body odors and halitosis apart from some occasional studies into trimethylaminuria (There are 5 listed on pubmed for 'trimethylaminuria' this year. 10 last year. Most of little significance) done by researchers who study lots of other things. The only estimates used is probably a 'DNA estimate' by geneticists, who at the 1999 1st TMAU Workshop mentioned they thought maybe 1% could be at risk (it's unknown if they are going by the 'strict' interpretation, that all sufferers will be autosomal recessive e.g. homozygotes).

However, there was a substantial 'real' snapshop testing survey done amongst a sample 'normal' British population In 1996 at the Imperial college in London, by 3 researchers. They tested 421 students of Imperial College Medical School at St. Mary's, London using the TMAU urine test. In the UK, they define a 'fail' as being less than 90% TMA-N-Oxide produced, and less than 80% as being "indicative of potential heterozygous status for deficient N-oxidation-fish odour syndrome" (which is surprising to read, since if medical students were taught about TMAU, they would likely be taught it is autosomal recessive e.g. homozygous)

The results were:
421 of a UK sample population tested
16 failed the 90% test (3.8% : seven male, nine female)
6 failed the 80% test (1.4% : all female)

So in a sample British population, 3.8% failed the urine test. 1.4% were not near the borderline. Nowadays, some researchers feel that it will be likely that people can pass the urine test but fail the test "in vivo" (i.e. in practice). 2 of the researchers are well known for publishing TMAU papers (especially around that time and the following few years), although they both likely have many other lines of research, and this is the only part of metabolic body odor they will focus on whenever they choose to do research along this line.

It makes you wonder how, for example, a Body Odor & Halitosis Research and Treatment Center would have reacted to such a study at the time. And how far the issue would have progressed both in treatment and how governments and medical systems would now view the issue.


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