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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Thursday, December 11, 2008

Baby with a portal shunt and later trimethylaminuria

A case of congenital portal-systemic shunting due to an intrahepatic connection diagnosed by ultrasound scanning and color Doppler in an 8-month-old girl is reported. She began to manifest trimethylaminuria 3 years later. At 7 years of age, she is asymptomatic without therapeutic measures except for diet. This is the seventh reported case and the third in a child to our knowledge.
This paper from 1997 is a case study about a baby girl who was diagnosed as having a hepatic portal shunt. This means her absorbed gut fluid (good and bad) is going directly into the systemic blood system unfiltered. Normally the absorbed fluid from the gut goes into the portal vein and then is carried to the liver to be filtered (often by the P450 and FMO3 enzymes etc). In her case there is a connection between the portal vein and the systemic system, so it bypasses the liver. This means her systemic system is subject to 'untreated' gut blood.

They say around age 3 she developed trimethylaminuria but it could be controlled by diet. One point to remember is that probably her liver metabolizing enzymes were normal. However, who knows what the girl would say what she smelt/smells of ? She would be perhaps around 19 now.

Another interesting popint is that medical students will be taught that someone with a portal shunt will be likley be on their death bed, whereas she seems to be fine. They say this is the 7th reported case in pubmed. Again proving the theory that people can have all sorts of gut metabolites in their systemic system and be 'healthy'.

It's very unlikely that most sufferers of metabolic body odor (including fecal body odor) have a portal shunt.


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