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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
click to read more
more details : karen.james@meboresearch.org

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Thursday, December 11, 2008

Baby with a portal shunt and later trimethylaminuria

http://www.ncbi.nlm.nih.gov/pubmed/9069234

A case of congenital portal-systemic shunting due to an intrahepatic connection diagnosed by ultrasound scanning and color Doppler in an 8-month-old girl is reported. She began to manifest trimethylaminuria 3 years later. At 7 years of age, she is asymptomatic without therapeutic measures except for diet. This is the seventh reported case and the third in a child to our knowledge.
This paper from 1997 is a case study about a baby girl who was diagnosed as having a hepatic portal shunt. This means her absorbed gut fluid (good and bad) is going directly into the systemic blood system unfiltered. Normally the absorbed fluid from the gut goes into the portal vein and then is carried to the liver to be filtered (often by the P450 and FMO3 enzymes etc). In her case there is a connection between the portal vein and the systemic system, so it bypasses the liver. This means her systemic system is subject to 'untreated' gut blood.

They say around age 3 she developed trimethylaminuria but it could be controlled by diet. One point to remember is that probably her liver metabolizing enzymes were normal. However, who knows what the girl would say what she smelt/smells of ? She would be perhaps around 19 now.

Another interesting popint is that medical students will be taught that someone with a portal shunt will be likley be on their death bed, whereas she seems to be fine. They say this is the 7th reported case in pubmed. Again proving the theory that people can have all sorts of gut metabolites in their systemic system and be 'healthy'.

It's very unlikely that most sufferers of metabolic body odor (including fecal body odor) have a portal shunt.

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