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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, April 13, 2009

genetically engineered bacteria : one possible treatment for TMAU

It has been hypothesized a decade or so ago by a researcher interested in FMO3 at the time (the late 90s were the heyday of FMO3 research amongst those few world scientists with an interest in subject), that one possible treatment could be genetically engineered bacteria that was enriched with FMO3 enzyme and could colonize the gut (presumably the colon). It could then detoxify the trimethylamine produced in-situ. This technology has probably been possible 10 or 15 years, and the main reasons it hasn't happened is likely that any scientist who has a history of FMO3 research is doing whatever they do (the last 2 'new research' TMAU papers over the last 2 years were possibly part of a researchers qualification papers, with the subject not to be returned to), and there is no orders from governments to do so.

This video demonstrates the principle. Rob Brown of the Australian TMAU support group has spoken of such research possibly happening in Australia, and it has been mentioned in the blog before. It would be a pity if it hasn't become a reality already, perhaps years ago, purely because it is thought there is no great need in society for such research.

This second video made by schoolkids for a project explains how the human insulin gene is genetically engineered into bacteria for diabetes. This seems to have had FDA approval since 1982. The only difference for TMAU would likely be that the patient would eat the bacteria, as a probiotic.


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