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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Monday, April 13, 2009

genetically engineered bacteria : one possible treatment for TMAU

It has been hypothesized a decade or so ago by a researcher interested in FMO3 at the time (the late 90s were the heyday of FMO3 research amongst those few world scientists with an interest in subject), that one possible treatment could be genetically engineered bacteria that was enriched with FMO3 enzyme and could colonize the gut (presumably the colon). It could then detoxify the trimethylamine produced in-situ. This technology has probably been possible 10 or 15 years, and the main reasons it hasn't happened is likely that any scientist who has a history of FMO3 research is doing whatever they do (the last 2 'new research' TMAU papers over the last 2 years were possibly part of a researchers qualification papers, with the subject not to be returned to), and there is no orders from governments to do so.

This video demonstrates the principle. Rob Brown of the Australian TMAU support group has spoken of such research possibly happening in Australia, and it has been mentioned in the blog before. It would be a pity if it hasn't become a reality already, perhaps years ago, purely because it is thought there is no great need in society for such research.

This second video made by schoolkids for a project explains how the human insulin gene is genetically engineered into bacteria for diabetes. This seems to have had FDA approval since 1982. The only difference for TMAU would likely be that the patient would eat the bacteria, as a probiotic.


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