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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country
MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts

MEBO TMAU Videos

Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
EURORDIS and
NORD Member Organization
See RareConnect

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :
https://forms.gle/vem2TjepKobYZPBu8

current participants : 113 (update 18dec20)

Tuesday, July 21, 2009

Article in March 2005 Orthodontic Cyberjournal about halitosis

Some extracts from an article in the Orthodontic Cyberjournal dated March 2005

Evaluation of expired air:

According to Delanghe et al.,87% of malodor originates from the mouth(9). The simplest way to distinguish oral from non-oral sources of maloder is to compare the smell coming from the mouth with that exiting the nose(5). Any potential nasal source of malodor is differentially diagnosed by directing the subject to seal the mouth and exhale only through the nose. A potential oral source of malodor is detected by directing the patient to pinch the nose closed and exhale through the mouth(10).

Pungent odor from the expired air can indicate lesions or disease of the nasopharynx, nose or sinuses. The nasopharynx is a common site of bacterial colonization contributing to bad breath. Any condition that alters the mucous membrane of the nose including atrophic rhinitis or rhinitis medicametosa can contribute to bacterial overgrowth and malodor. Chronic sinusitis, unilateral choanal atresia and nasal foreign bodies also cause halitosis(10).

If the same malodour is detected from both nasally and orally expired air, a systemic or respiratory tract source should be suspected(10). Malodor can be an early symptom of nasal tumors. Referral to an otolaryngologist is indicated if infection, foreign body or neoplasm of these structures is suspected.

A more noxious odour found in the orally expired air than air expired nasally can indicate an oral, oropharyngeal, hypopharyngeal or, rarely, a gastric source (10).

The results of a study by Tonzetich, Peti and Huggins (1978) provided a satisfactory explanation of this phenomenon when they reported finding distinct variations of hydrogen sulfide, methyl mercaptan and dimethyl sulfide in mouth air during different stages of the menstrual cycle.Menstruation:

It has been reported that during menstruation or certain menstrual cycles(Massler, Emslie and Bolden, 1951), some women have bad breath. This is most likely secondary to hormonal changes. The results of a study by Tonzetich, Peti and Huggins (1978) provided a satisfactory explanation of this phenomenon when they reported finding distinct variations of hydrogen sulfide, methyl mercaptan and dimethyl sulfide in mouth air during different stages of the menstrual cycle.

Pathologic causes of halitosis
Non-oral(Systemic) causes of halitosis:

Odors can be derived from the mouth, the lungs, and the nasal passages. Any putrefaction in the lungs or in the nasal passages would also give off odiferous substances during the flow of air in the process of breathing...


Full article:
http://www.oc-j.com/mar05/Halitosis-Part_1.htm

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