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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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to join : go to
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Wednesday, August 12, 2009

Interest in MeBO gut dysbiosis study in the UK

Are you interested in the MeBO gut dysbiosis study in the UK ?
MeBO is currently setting up a small study through Biolab in London for the testing of a few biomarkers of various types of gut dysbiosis. At the moment, MeBO cannot cover funding of such testing, since it has only been in operation for one month, so anyone volunteering would need to pay for their own tests.

The 4 tests chosen are the following (with financial concerns in mind), and sufferers may test for any or all of them :

Indicans urine test £13 (can be done from home)
D-lactate blood test £12 (requires a blood sample)
Biolab gut fermentation test £46 (must attend Biolab)
Gut permeability test £75 (urine test. can be done from home)

The results will be collated to see if there are any patterns. Two researchers have kindly accepted to oversee the project and interpret the results. Each person will receive a copy of his or her results.

If anyone is provisionally interested they could send an email to expressing interest and indicating which tests they would like to do. MeBO will sort out the testing procedure in the next few weeks. Since Biolab is in London, it seems it may only be viable for testers in the UK & Ireland and neighbouring countries. The indicans test can be done from home, but blood must be drawn for the d-lactate test, and the lab must be attended for the gut fermentation test. Biolab could also do the d-lactate test there on the same day.

The study is especially aimed at investigating 'fecal body odor syndrome', including anyone who has been diagnosed positive for TMAU, but since testers are paying, anyone with a body odor or halitosis problem may test. Testers will be required to fill out a short questionnaire so as to determine what type of odor problem each tester has.

More details will follow later

The object of the study is to test some biomarkers for general gut dysbiosis.

At the moment, for 'fecal body odor syndrome', it is not known what the factors are, but the suspicions lie within the following areas :
genetics : FMO3 in particular
metabolism : Possible metabolic weakness
detoxification : especially the biotranformation enzymes
gut ecology : especially gut dysbiosis
vitamin/mineral status

This study is looking at certain biomarkers of gut dysbiosis, including gut candidiasis.
  1. Indicans test: Indicans would be a straightforward and inexpensive way of looking for intestinal toxaemia and overgrowth of anaerobic bacteria, and would be an interesting approach, requiring a mid-stream, early morning, urine sample.
  2. D-lactate test: D-lactate is a specific bacterial metabolite and would not normally be found in blood unless there is a bacterial infection. So for patients with gut symptoms it looks as if this might be an interesting way of looking for intestinal infections. The symptoms of such infections can be quite wide-ranging and a recent publication found a correlation with chronic fatigue (suggesting there may be a bacterial cause).
  3. Gut fermentation profile: Involves gas chromatography technique. Tests for alcohols associated with gut candidiasis and bacterias.


The form to test in MeBO-Biolab Gut Dysbiosis Study is here :
MeBO-Biolab gut dysbiosis in body odor or halitosis study form-REVISED

Donate to MeBO Research

What MeBO is doing

MeBO Research aims to become a charity focusing on systemic body odor and systemic sourced halitosis, particularly 'bowel smells' body door, since it is the most common. Any donations are welcome to primarily reach MeBO's aim of charity status. As a charity, MeBO can then pursue grants and endowments in order to carry out large-scale international studies.

related links :
Dr Myhill article on Biolab gut fermentation test
Interview with Mark Howard : Biolab manager


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