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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

UK residents survey : Prof Shephard/MEBO (until 31/1/21) click to visit survey
click to Read more/less

Prof Elizabeth Shephard is conducting a TMAU fact-finding survey for UK RESIDENTS. She plans to use it to raise awareness with decision-makers, such as perhaps MPs. It closes 31 Jan 21.

who is the survey intended for ?
UK residents who identify with TMAU

Living with TMAU study

We invite you to participate in a research project entitled ‘Living with TMAU’.

click to visit survey

survey full url :

Participation in the project will involve completion of a short questionnaire, which aims to capture the experiences of those living with the condition. There are two questionnaires.

For individuals with TMAU over the age of 18

For a parent or guardian of a child with TMAU.

The results from the questionnaires will be compiled to produce a report that will be available for you to use, for example, to lobby your MP. The findings will be used to reach out to policy makers in the UK to have TMAU recognised as an invisible disability and to make people aware of what it is like to live with the disorder. The report will be made available on the MEBO, UK website.

To complete either questionnaire you must be over 18 and resident in the UK. The questionnaire responses are anonymous and no personal identifiers will be collected.

The questionnaire closes 11:59 pm (GMT) Sunday 31st January 2021.

MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Wednesday, August 26, 2009

Pubmed paper 2009 : Actions of Cree anti-diabetic plants on human cytochrome P450 isoforms and flavin-containing monooxygenase 3

Actions of ethnobotanically selected Cree anti-diabetic plants on human cytochrome P450 isoforms and flavin-containing monooxygenase 3

Regular readers will know that FMO3 enzyme is always of special interest to the blog. This is the latest pubmed paper about the enzyme, albeit only in a limited way.

The testers were testing the phase1 xenobiotic metabolizing enzymes to see how they are affected by natural medicines used by Cree Indians in Canada.Normally when researchers check reactions in phase 1 xenobiotic metabolizing enzymes, they only check the Cytochrome P450 super-family, even though the FMO family come into this category. This is probably because at the moment the FMO enzymes are perceived as unimportant. So it was good to see FMO3 tested in this test as well.

Probably the main reason for interest in these enzymes is that drugs are metabolized by them, and they can also have an inhibitive or inducing effect on the enzymes. Probably one priority to pharmaceutical industry testers is the thought of lawsuits. These enzymes have only been properly known about for about 50 years, and so a lot has still to be learnt about them, especially the FMO family. Presumably the tests were done 'in vitro' at a lab, rather than 'in vivo'.

The 'textbook' definition of FMO enzymes will say it can neither be induced or inhibited, even though those using the same definition have found a compound in cruciferous vegetables to be very inhibitive. In this study, FMO3 seemed to be 'middling' inhibited by the plant extracts used. However, it's not known how conclusive such studies can be, since often there are other conflicting papers published. Perhaps the 'behaviour' of a xenobiotic metabolizing enzyme isn't accepted until a definite trend in papers is seen.

Herbs and spices are of special interest in FMO3 because most are likely FMO3 'substrates' and also may have an inhibitive/inducing effect (currently unknown). This may explain why when taking herbs/spices/medicines, some may feel 'strange' and perhaps get pain around the liver (since the liver is the most prominent place where such enzymes are based).

body odor

phase1 : modify a compound
phase2 : add a molecule to a compound; conjugate

These enzymes deal with internally produced compounds (neurotransmitters, hormones etc) as well as external compounds (from diet and environment etc)

The most abundant area for these enzymes is the liver, but they are everywhere.


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