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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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London TMAU meeting with Prof Liz Shephard
19th Oct 11am - 1pm
St Mary's Hospital
Praed St, Paddington
London W2 1NY
click to read more
more details : karen.james@meboresearch.org

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Tuesday, June 8, 2010

MeBO-Biolab gut dysbiosis study : Tester 10 results


Tester 10
Female
late 20's
Odor problem:
The smell varies:
Ammonia
Fecal
Smoke
Garbage
Certain foods if ingested (i.e. onion). Had problem for 9 months
Gut problems
Gas, slow digestion, excess of gas in the stomach (not in the bowel), bad taste in the mouth (of chemical), change in the colour of the tongue (white/brown)- thrush test negative
Other problems
Generally fit and well
Other symptoms that have appeared with the odour are:

Increase of mucus at the back of the throat
Increase sweating in palms
? Skin more oily
TrimethylaminuriaSecondary TMAU, with increased TMA/TMAO ratio in urine test


Results :
Tester 10
Gut FermentationNormal
body odor tester 10 gut fermentation result
Gut permeabilityIncreased permeability between 330-374
body odor leaky gut tester 10
IndicansNegative
body odor tester 10 indicans dlactate
D-lactate2 (normal is under 60)

Vitamin B2
1.09 (below is 120 normal)body odor tester 10 vitamin B2 result

The results of tester 10 in the MeBO-Biolab gut dysbosis study are back (in cases of body odor and halitosis suspected as being systemically caused)and this time the results seem very normal. A slight gut over-permeability between molecule weight 330-374 seem to be the only abnormality. Of special interest in this case is that the tester had already been diagnosed with Secondary TMAU, meaning an excess of trimethylamine thought to be caused by bacteria in the gut. She had been on antibiotic treatment twice since then, 5 months prior to this gut dysbiosis study, specifically for TMAU2, and is scheduled for her third course of antibiotics soon.

In her presentation for our blog, ‘Microbes and Us’, Dr. Irene Gabashvili explains that through time, a dysbiosis can injure the intestinal wall resulting in an increase or decrease in permeability. It would be interesting to see if the antibiotic treatment for the TMA-producing bacteria has improved this tester's gut permeability, and if it would improve further as the treatment continues.

This is our 4th tester of vitamin B2 status, and the first such tester to be normal for B2 function. Some of the alcohols in the gut fermentation test appear slightly raised (but not ethanol, thought to be caused by yeast overgrowth) but no comment is made of this, so it may not be significant. The range of smells mentioned by the volunteer seem typical of most cases in the study. In the biomarkers tested in this study, this set of results seem very normal.

Tester 11 results should be in within the next couple of weeks. Thank you to tester 10 and all the testers for taking part in the study.

Anyone wishing to take part in this systemic body odor or halitosis study can fill out the MeBO-Biolab body odor/halitosis gut dysbiosis survey and the process will begin. Each volunteer has to pay their own testing costs, which are £170 plus any other costs. It would be especially interesting to see how those who were positive for TMAU would get on with these tests. Unfortunately, those overseas from the UK seemingly cannot do the vitamin B2 test, since the sample will likely be spoiled in transit. Testers need to pay for their own tests.

The tests are seen only as a starting point for exploratory testing into possible causes of systemic body odor and halitosis.

A table of the summary of results is kept on the MeBO Research website. no identifiable information is ever disclosed.

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