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MEBO TMAU TESTING CURRENTLY SUSPENDED INDEFINITELY

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

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Full details : https://goo.gl/TMw8xu
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TMAU UK end total:262
TMAU UK ends 23/01/20
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USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Monday, June 21, 2010

MeBO-Biolab gut dysbiosis study : Tester 11 results

Tester 11
Male, early 30's
Odor problem:
Body odor and halitosis problem. Smells include body odor, fish, sometimes garbage. Had problem for around 15 years. Negative TMAU urine test. Cannot make a connection between diet and smelling, but does with sexual activity
Gut problems
Gas
Other problems
No obvious problem
TrimethylaminuriaNegative urine test


Results :
Tester 11
Gut FermentationEthanol normal.
Raised for 2,3 butylene glycol
Tester comments it shows probable BACTERIAL dysbiosis
Gut permeabilityRaised between 242 and 550 (leaky gut)
body odor gut permeability test 11
IndicansPositive

D-lactate503 (normal is below 60)
Vitamin B2
1.11 (normal is below 1.20)

Tester 11 results are back and this is an interesting case both in what he feels provokes the symptoms, and also the pattern of the results themselves. The tester, a male in his early 30's who had had the problem for around 15 years, cannot make a connection between diet and odor occurrences, but makes a certain connection with sexual activity. There are too many speculative reasons why this would be, including possibly something to do with hormones and other chemicals released in the bloodstream.

As for the results, the tester was fine for ethanol (implying yeast gut infection) which has been quite a common trend in our study. Instead his gut fermentation test came back as 'probably bacterial dysbiosis'. This seems to be mainly due to the 2,3 butylene glycol result. This is the first 'bacterial dysbiosis' gut fermentation result we have had, although others have had alcohols higher than normal but the lab did not seem to think them significant enough.

The indicans test is positive, which is generally thought to imply an overgrowth of putrefactive bacteria, and the d-lactate was extremely high. D-lactate is regarded as being produced by lactic-acid producing bacteria from carbohydrate fermentation. This is only the 2nd person to have a high d-lactate result. We were planning on discontinuing this test, but will keep it as an option now.

Gut permeability was also increased (meaning 'leaky gut'); the 7th of our testers that has raised permeability at some stage in the graph.

B2 was normal. Only 4 other people have tested for B2, with 3 being deficient. 2 of them also had raised ethanol.

Overall, this testers results do seem to indicate a bacteria overgrowth issue in the gut of some kind, but not a yeast issue.

Related links:
Biolab PDF on d-lactate

About the MeBO-Biolab gut dysbiosis study


The MeBO-Biolab gut dysbiosis study is a sufferer-led project under the guidance and supervision of Dr. Irene Gabashvili, started by MeBO Research with the help of Biolab Medical Unit in London to use a number of tests from Biolab that specifically test for biomarkers of gut dysbiosis, including yeast overgrowth, certain bacteria overgrowth, and 'leaky gut'. Each volunteer needs to pay for their own tests. The criteria for the tests were total cost, and the tests on offer. Although the study is intended as an example of what health-problem communities could achieve with the internet nowadays; it also hopeful the tests in themselves will be useful, although no direct co-relation can be made with the results and your odor problem. To be included in the study, please fill in the survey and you will be contacted by email.



Summary of all testers results so far :MeBO Biolab gut dysbiosis study in systemic body odor

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