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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Friday, December 23, 2011

Soluble form of human FMO3 for 'in vitro' experiments

Regular readers will know that the enzyme flavin mono-oxygenase isoform 3 (FMO3) is of particular interest to MEBO, given that it oxidizes many 'smelly' sulfide and amine compounds (and is 'officially' recognised as being the enzyme at fault for trimethylaminuria). Since enzymes deal with particular chemical structures, this means it deals with compounds that can be sourced from various sources; such as the gut flora, internally produced 'biogenic' amines (eg hormones etc), and drugs.

In the pharmacology industry FMO3 would be referred to as a 'drug metabolizing enzyme', partly because they will be trying to understand how their drug is metabolized in humans to 'help' them, and partly because they will afraid of future lawsuits due to bad reactions. Probably most understanding of the 'drug metabolizing enzymes' is discovered for these reasons.

FMO3 seems to have been the 'neglected' enzyme in this group of enzymes, but it seems it is finally getting some attention. So it is good to see that some researchers have come up with a form of FMO3 that seems to be easier to do 'in vitro' (analogy : in a test tube). It seems to be a soluble form that is easier for researchers to work with. Let's hope it is a technical leap of some sorts.

...The use of this soluble form of the hFMO3 enzyme as opposed to the usual microsomal preparations is advantageous for in vitro drug metabolism studies that are a requirement in the early phases of drug development by pharmaceutical industry.

Pubmed abstract : In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3
Other FMO3 links
Flavin Mono Oxygenase : The other oxidase
Wikipedia : FMO enzyme family
FMO enzyme family : Structure, polymorphisms and role in drug metabolism


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