Commencing the MEBO VOC Alveolar Breath Test and Exploratory Research Study

MEBO/Menssana Alveolar Breath Exploratory Study

VOC TEST AND
RESEARCH STUDY
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for more info contact mike@meboresearch.org

Requisition Form

sufferers are strongly encouraged to express interest by filling out the Requisition Form as soon as possible in order to encourage MEBO to schedule testing in their area of the world...

Test sites will be determined based on the demand in the area indicated by the amount of Requisition Forms received. If you are interested in participating in this test/study, please fill out the Requisition Form so that MEBO may consider a testing location that you can attend. An invoice with a PayPal button will be sent 45 to 30 days prior to the testing date to persons who filled out the Form, and payment must be received prior to testing. However sufferers are strongly encouraged to express interest by filling out the Requisition Form as soon as possible in order to encourage MEBO to schedule testing in their area of the world, if enough interest is indicated in that area.


INITIAL TEST SITES:

1. Chicago, Illinois, on April 21st & 22nd, 2012
   Email: mike@meboresearch.org
2. in Birmingham, England June 9th, 2012
3. Miami South Beach, Florida, Annual Meetup in June 23rd & 24th.

MEBO Research (MEBO) is happy to announce the launching of our Alveolar Breath Exploratory Study. Menssana Research, Inc., (Menssana) has shipped the BCA 5.0 instrument to MEBO's Managing Director, Mike, in Chicago, and we will have use of this instrument for a period of one year. The use of this BCA 5.0 instruments was donated free of charge for one year, when normally it is leased out, by Dr. Michael Phillips, MD, PACP, Professor of Clinical Medicine at New York Medical College, Valhalla, New York, while MEBO works at obtaining as many samples as possible worldwide. If we wish to continue using it for more than a year, we would have to lease it. Therefore, MEBO will be collecting samples only through early March 2013, and the instrument must be returned to Menssana by March 22, 2013. It is our intent to make good use of this equipment by holding testing sessions as frequently as possible in as many parts of the world as we can logistically organize. Additional sites will be determined based on the demand in the area indicated by the amount of Requisition Forms received. If you are interested in participating in this test/study, please fill out the Requisition Form so that MEBO may consider a testing location that you can attend.

The cost of the test is $345/USD per person. This amount does not cover the total cost of this study, and therefore, donations are welcome using the donate button provided below. This exploratory study will benefit our body and breath malodor community, as this is only an initial step towards discovering the causes, treatment, and ultimately, the cure for all types of body odor and halitosis conditions.

MEBO VOC Alveolar Breath Exploratory Study

NOTE: An invoice with a PayPal button will be sent to you 45 to 30 days prior to the testing date, and payment must be received prior to testing. However sufferers are strongly encouraged to express interest by filling out the Requisition Form as soon as possible in order to encourage MEBO to schedule testing in your area, if enough interest is indicated in your area.

In 2008, MEBO had identified a range of chemicals and their associated odors. Using the table below, Menssana Research Laboratory conducted extensive research utilizing their toxicology database and combing through 700-800 patients profiles to identify the higher concentrated chemicals (four carbon atoms and above) that mostly affect the community. We received the report from the Menssana Laboratory and placed the information in this table below. Dr. Phillips and the Menssana team have been very open with working with MEBO, and empathetic to the needs of the sufferer community.

The volatile organic compounds are identified through breath by apparatus provider to MEBO by Menssana. The VOCs’ are transferred to the breath via the gas exchange in the alveolar ducts within the lungs. The test will measure the level of 200 volatile organic compounds present in the breath, including those noted in the chart.

CHEMICAL	ODOR	ORIGIN	BREATH TEST (detect or highly plausible)
hydrogen sulfide	rotten eggs	sulfur compound, methionine
methylmercaptans	rotten cabbage		Yes – specifically saw ethylmercaptan, 1- (4-methoxymethyl) phenyl – and 3-Methylbenzyl mercaptan
diethyl - sulfide	rotten vegetables		Yes
acetic acid	vinegar	phenolic compound	Yes – both pure and branched chain derivatives
phenol	medicinal, sweet	tyrosine	Yes – both pure and derivatives
p-cresol	fecal	tryptophan, tyrosine	Yes – specifically 4, 6-di-tert-butyl-m-cresol
butanoic acid (other name: Butyric acid)	rancid butter	fiber, histidine	Yes – pure and derivatives
butyric	sour meat
methionine	rancid butter	sulfur, carnitine
indole	mothball, fecal	tryptophan	Yes – pure and derivatives
Methylamine (derivative of ammonia)	fishy, pungent	nitrogen compound
dimethylamine	ammonia-like odor	secondary amine	Yes – possible derivatives
Diethylamine		secondary amine (strong odor, volatile, alkaline)
ammonia	sharp, pungent
indol	fecal	Tryptophan (indolic amino acid)
Skatole (belongs to the indol family)	fecal, pungent	tryptophan
Acetylaldehyde	fruity, pungent	(a product of alcohol metabolism in liver)	Yes
acetone	sweet, fruity, pungent		Yes
2-aminoacetophenone	musky, grape-like
" " + indole	wet dog
methylcrotonic acid	cat urine	organic acid, acid
isovaleric acid	sweaty feet; strong punget cheesy or sweaty smell	leucine
phenylalanine	musty/mousy	amino acid	Yes – 4-phenylalanine – only derivatives
branched chain amino acids	Sweet maple syrup smell of the urine	amino acid	Yes – specifically identified leucine, isoleucine, and valine
2-nonanone	Banana-like fruity		Yes
trimethylamine	fishy, ammoniacal	choline
cadaverine	rotting corpse	lysine
dimethylglycine	fishy	choline
caproic/capric acid	sour/goat like odor	short chain fatty acids	Yes – pure and derivatives under synonym (hexanoic acid)
napthalene			Yes
bytyric acid	Acrid, Butter, parmesan cheese, vomit	Product of anaerobic fermentation in gut	Yes – pure and derivatives

TESTING AND RESEARCH STUDY FORMAT
Testing will take place in groups at different locations throughout the world, depending on demand demonstration in the Requisition Forms filled out by sufferers, over a one year period. The data from individuals will be analysed by Menssana, and individual test results should be available to patients within two weeks. Testing will be carried out by trained MEBO staff, and patients are advised not to eat anything three hours prior to testing.

PRICIPLE ELEMENTS OF TESTING AND RESEARCH STUDY

1. Identifies over 200 different volatile organic compounds
2. Identified VOC have an associated odour, see fig 1
3. Provides information that may enables suffers to identify dietary restrictions and an individually tailored protocol
4. Research study will be conducted with the following hypothesis: What are the evident trends in VOC among sufferers, how do they relate to an observed normal population
5. The ability for patients to compare results to a group with similar malodor complaints, and to a normal population.

The study of the compiled data will not commence until all individuals have been tested throughout a years times along with a normal population to compare all data collected. Comparison with an observed normal population should conclude the relevant range acceptable in the breath. Trends in deviation between patients and the normal population should give conclusions to the extent of the problem. Individual results will then only have conclusive relevance at the end of the full research study.

This research study is driven by sufferers united under MEBO Research's banner, in consultation and supervision of experts and our Institutional Review Board, to initiate formal studies to find answers to all types of body and breath malodor conditions. Its success relies heavily on the participation of sufferers from around the world in order to obtain a more accurate "picture" of our international community. The more data we compile, the greater the relevance of the results to our vast international community. Please be a part of this sufferer-driven movement by filling out the Requisition Form and committing to participate in this study, and let's show the world that we are a significantly large community who merit support in our ventures to find a cure.

María

María de la Torre
Founder and Executive Director

A Public Charity
www.meboresearch.org
www.brasil.meboresearch.org
maria.delatorre@meboresearch.org
MEBO's Blog (English)
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For additional posts on this topic, please click here:
Alveolar Breath Test/Research Study.

*Menssana Research Publications

1. The IADR/AADR/CADR 83rd General Session (March 9-12, 2005), Prediction of Oral Malodor with Volatile Markers in the Breath.
2. Oral Diseases (2005); 11 (Suppl. 1): 32-34. Pilot study of a breath test for volatile organic compounds associated with oral malodor: evidence for the role of oxidative stress.
3. European Respiratory Journal (2004); 24: Suppl. 48, 467s. Volatile markers of pulmonary tuberculosis in the breath.
4. Workshop on TB and HIV Diagnostics in Adult and Pediatric Populations, sponsored by NIH and FDA, Silver Spring, MD (June 29, 2011)
5. Journal of Breath Research (Jan.22, 2010)Effect of influenza vaccination on oxidative sgtress products in breath.
6. Clinica Chimica International (CCA), the International Journal of clinical chemistry and Diagnostic Laboratory Medicine, CCA10989 (May 31, 2008)Detection of lung cancer using weighted digital analysis of breath biomarkers.
7. Journal of Clinical Oncology 2005; 23(16S): 839 S. Floor presentation at 2005 ASCO Annual Meeting, Orlando, Florida, May 16, 2005, Prediction of Lung Cancer Using Volatile Biomarkers in Breath.
8. IOPScience, (Mar. 2, 2010). The Institute of Physics (IOP) is a not-for-profit society that provides publications through which leading-edge scientific research is distributed worldwide. Volatile biomarkers in the breath of women with breast cancer.

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