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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Friday, June 1, 2012

Hormonal influence on olfactory acuity as well as body and breath odor

An article written by the Food Neurochemistry Lab at the University of Panama, The amelioration of olfactory acuity upon sexual maturation might affect food preferences, raises an interesting point about olfactory acuity in women improving as one matures sexually (15-44 year-old women). Even more interesting, it discusses how the olfactory acuity seems to fluctuate throughout the menstrual cycle, “During ovulation, mean olfactory threshold is 30 times lower than during bleeding.”

During ovulation, mean olfactory threshold is 30 times lower than during bleeding. Interestingly, menstruated women undergo maleodorant trimethylaminuria. We argued that olfactory amelioration during ovulation might concur to a mating strategy, whereas olfactory impairment during bleeding might protect women against self-refusal.
The explanation given seems to be more focused on testosterone levels, as opposed to estrogen levels in women, as the testosterone derivative “might be responsible for the synchronization of these menstrual events.”

One of MEBO’s Scientific Advisors and pioneer in the science of TMAU, Dr. John Cashman of HBRI and Professor Yamazaki, et al., have published a paper, Transient trimethylaminuria related to menstruation (2007), in which they conclude,

…these results indicate that abnormal FMO3 capacity is caused by menstruation particularly in the presence, in homozygous form, of mild genetic variants such as [Glu158Lys; Glu308Gly] that cause a reduced FMO3 function.

there seems to be a parallel pattern between increased olfactory acuity and transient TMAU in sufferersAs a community of body odor and halitosis sufferers, we consequently raise the following questions as to whether a similar effect of hormonal changes hold true in relation with body and breath odor conditions. Based on these papers, there seems to be a parallel pattern between levels of olfactory acuity and transient TMAU in sufferers.

The figures used in this article present a

Hypothetical view of the multiple physiological processes concurring to modulate olfaction and liver FMO3 enzyme activity i women during menses. (CYP19A1 = Aromatase enzyme; Estradiol = 17β-Estradiol; TMA = Trimethylamine; TMAO = Trimethylamine oxide; FMO3 = Flavin mono-oxygenase 3; DA interneurons = Dopaminergic neurons; hPR = Progesterone receptor).

See other posts in this blog under the label "hormones" (and scroll down to see them all) related to the effects of hormonal changes body/breath odor.


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