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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Friday, June 1, 2012

Hormonal influence on olfactory acuity as well as body and breath odor

An article written by the Food Neurochemistry Lab at the University of Panama, The amelioration of olfactory acuity upon sexual maturation might affect food preferences, raises an interesting point about olfactory acuity in women improving as one matures sexually (15-44 year-old women). Even more interesting, it discusses how the olfactory acuity seems to fluctuate throughout the menstrual cycle, “During ovulation, mean olfactory threshold is 30 times lower than during bleeding.”

During ovulation, mean olfactory threshold is 30 times lower than during bleeding. Interestingly, menstruated women undergo maleodorant trimethylaminuria. We argued that olfactory amelioration during ovulation might concur to a mating strategy, whereas olfactory impairment during bleeding might protect women against self-refusal.
The explanation given seems to be more focused on testosterone levels, as opposed to estrogen levels in women, as the testosterone derivative “might be responsible for the synchronization of these menstrual events.”

One of MEBO’s Scientific Advisors and pioneer in the science of TMAU, Dr. John Cashman of HBRI and Professor Yamazaki, et al., have published a paper, Transient trimethylaminuria related to menstruation (2007), in which they conclude,

…these results indicate that abnormal FMO3 capacity is caused by menstruation particularly in the presence, in homozygous form, of mild genetic variants such as [Glu158Lys; Glu308Gly] that cause a reduced FMO3 function.

there seems to be a parallel pattern between increased olfactory acuity and transient TMAU in sufferersAs a community of body odor and halitosis sufferers, we consequently raise the following questions as to whether a similar effect of hormonal changes hold true in relation with body and breath odor conditions. Based on these papers, there seems to be a parallel pattern between levels of olfactory acuity and transient TMAU in sufferers.

The figures used in this article present a

Hypothetical view of the multiple physiological processes concurring to modulate olfaction and liver FMO3 enzyme activity i women during menses. (CYP19A1 = Aromatase enzyme; Estradiol = 17β-Estradiol; TMA = Trimethylamine; TMAO = Trimethylamine oxide; FMO3 = Flavin mono-oxygenase 3; DA interneurons = Dopaminergic neurons; hPR = Progesterone receptor).

See other posts in this blog under the label "hormones" (and scroll down to see them all) related to the effects of hormonal changes body/breath odor.


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