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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Wednesday, February 6, 2013

Graph of TMAU results from Sheffield 1997-2012

Sheffield TMAU results : 1997 - 2012
Graph of TMAU urine test results tested at Sheffield Children's Hospital 1997-2012

Kindly given to MEBO Research by the tester ; Nigel Manning : Principal Clinical Scientist, Dept of Clinical Chemistry, Sheffield Children's Hospital, Sheffield.

Nigel Manning has kindly given MEBO Research a graph of all the TMAU biochemical test results done by his lab at Sheffield Children's Hospital since his lab started testing in 1997 up until the end of the 2012. This is an updated graph of one given to MEBO Research in a previous year.

Sheffield Children's Hospital TMAU urine test reference range :
The lab tests the trimethylamine and trimethylamine oxide levels in urine samples. The reference ranges used by the lab are (for a normal person):
That the TMA level should be lower than 11 umols/mmol creatinine
That the TMA/TMAO ratio should be lower than 0.21 (this as a % works out at >79% TMAO)

So from the graph it can be seen that those in the small square in the bottom left are 'normal'. Those above the horizontal red line have TMAU2 (too much trimethylamine), and those to the right of the vertical red line have genetic TMAU (TMA/TMAO ratio too high). In total, 1731 samples have been tested in the graph.


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