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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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NORD Member Organization
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Monday, March 9, 2015

IGEM 2014 competition : French graduates produce enzyme that neutralizes trimethylamine

tmau research
Click for project link
French graduates based at a Paris University genetically engineered a skin bacteria to make it rich in an enzyme (trimethylamine mono-oxygenase) that oxidizes (neutralizes) trimethylamine to TMA-oxide. The experiment was for an annual international genetic engineering contest for undergraduate teams (IGEM 2014) and was proven to work in a lab (i.e. the concept of proven 'in a test tube').

Link : Something Fishy (IGEM 2014)

The undergraduate team are based at
Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal,
South wing, 2nd floor
Paris Descartes University

The team seem to be called 'Paris Bettencourt' for the annual competition. Perhaps most of their funding is by the Bettencourt Foundation (Bettencourt being the founding family of L'oreal brand).

The experiment :
The experiment to oxidize trimethylamine was one of 4 projects they did in relation to body odor and genetic engineering. In this project, they took a TMA oxidizing enzyme (trimethylamine mono-oxygenase) from a non-human bacteria (Ruegeria pomeroyi) and put it in  E.coli and Corynebacterium striatum, a skin-native bacterium.

Results :
It seems that they were able to put the TMA oxidizing enzyme into E Coli and the Corynebacterium striatum which is a skin-native bacterium 

They put the genetically modified TMM rich E Coli in a TMA liquid and it did oxidize much of the TMA to TMAO.

Possible applications :
They mention the possibility of a TMM-rich bacteria added to a spray or cream to put on the skin and eliminate TMA on the skin.

Presumably another possibility is to make a GM  skin-native bacteria rich in TMM enzyme that could be nurtured to live on humans (?)

Possibly an internal therapy answer could be formulated , such as a TMM rich probiotic.

Final comment :
The big question is whether these types of answers are only possible now or could have been found earlier but have not due to no interest in TMAU/FMO3 by the research community overall. It is also not known if the above project is being followed up on. 

The project says TMM is not just TMA specific, so perhaps it will work on other/all smelly substrates which may be the same as FMO3 substrates.

Desulfovibrio desulfuricans :
The project also seems to 'blame'  Desulfovibrio desulfuricans bacteria as the cause of degradation of choline to TMA. This is the first time I have heard of this connection. It is interesting because it has been a bacteria of suspicion and is mostly known for producing hydrogen sulfide (H2S) from sulfates. Many people with metabolic malodor and TMAU report of smelling of 'rotten egg' which H2S is one known possible source of this smell.           


Unknown said...

This is a great news. I hope to do the same thing only working in the digestive system or stomach.

Apr 3, 2015, 9:20:00 AM
Anonymous said...

I hope that these students continue to one in their research to possibly find the cure for this condition, because it seems like the researchers and experts that we have working on this right now, is really slow in giving the people any bit of info, whether being good or bad, i mean people have to right to be updated on how things are goin. Good job students, and continue to keep up the good work...god bless u

Apr 3, 2015, 4:51:00 PM
Anonymous said...

God doesn't exist!

May 22, 2015, 6:08:00 PM
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