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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


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TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Wednesday, December 21, 2016

Asian herbal mushroom and FMO3 induction

A Korean research paper last week claims that an asian mushroom commonly used by Korean Herbalists could induce FMO3.

mushroom : Phellinus baumii 

Korean paper (University of Seoul, Seoul, Korea):
Korean herbal mushroom induces FMO3 in mice in research paper.

Quote :
"PBE was responsible for the induction of Fmo2, Fmo3, and Fmo4 expression. PBE also accelerated the metabolic clearance of carbendazim in vivo and so could be applied to the detoxification of xenobiotics such as drugs, pesticides, and nicotine."
pubmed link to abstract

Keeping in context :
This is a one-off paper.
One-off papers come and go about almost any health aspect (i.e. butter good/bad ).
Perhaps their expertise is in Korean Herbalism.
It's unknown how the mushroom may affect other enzymes etc.

FMO3 Induction as a potential therapy :
The usual teaching is that FMO3 cannot be induced/inhibited. This is despite the fact there have been papers showing FMO3 inhibition (indoles in cruciferous veg, during menstrutation).

So this is possibly the first time a 'non-pathogenic' compound has been shown to INDUCE FMO3. (a very cancerous compound previously was, again a one-off paper.

It has been speculated that FMO3 INDUCTION could be a potential therapy in that it may increase function by a few % (e.g. 10%, 20%). So if a harmless compound(s) could be found, it may be a potential therapy for 'text-book' FMO3 deficiency (not sure about those with TMAU2. Perhaps indirectly, but seems unlikely).

A current thought on this paper :
People in the TMAU community often complain of side-effects from potential 'FMO3 therapies'. FMO3 probably alters many compounds derived from plants. FMO3 has been part of living things probably from early evolution. A theory is that FMO3 was developed to dela with plant poisons (in the animal/plant evolution warfare). So with FMO3 deficiency it may be a case of the meat/poison saying.
So any lead in this area should probably be viewed with caution, perhaps expecting it to do more worse than good.

Wikipedia entry for FMO's 
"FMOs have gained a lot of attention in drug development since these enzymes are not readily induced or inhibited by the chemicals or drugs surrounding their environment.[14] CYPs are the primary enzymes involved in drug metabolism. However, recent efforts have been directed towards the development of drug candidates that incorporate functional groups that can be metabolized by FMOs. By doing this, the number of potential adverse drug-drug interactions is minimized and the reliance on CYP450 metabolism is decreased."

Cashman paper 2006 
 "In contrast to cytochrome P450 (CYP), FMO is not easily induced nor readily inhibited"

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Anonymous said...

Were in the USA can I purchase the herb

Dec 26, 2016, 5:47:00 PM
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