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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Wednesday, December 21, 2016

Asian herbal mushroom and FMO3 induction

A Korean research paper last week claims that an asian mushroom commonly used by Korean Herbalists could induce FMO3.

mushroom : Phellinus baumii 

Korean paper (University of Seoul, Seoul, Korea):
Korean herbal mushroom induces FMO3 in mice in research paper.

Quote :
"PBE was responsible for the induction of Fmo2, Fmo3, and Fmo4 expression. PBE also accelerated the metabolic clearance of carbendazim in vivo and so could be applied to the detoxification of xenobiotics such as drugs, pesticides, and nicotine."
pubmed link to abstract

Keeping in context :
This is a one-off paper.
One-off papers come and go about almost any health aspect (i.e. butter good/bad ).
Perhaps their expertise is in Korean Herbalism.
It's unknown how the mushroom may affect other enzymes etc.

FMO3 Induction as a potential therapy :
The usual teaching is that FMO3 cannot be induced/inhibited. This is despite the fact there have been papers showing FMO3 inhibition (indoles in cruciferous veg, during menstrutation).

So this is possibly the first time a 'non-pathogenic' compound has been shown to INDUCE FMO3. (a very cancerous compound previously was, again a one-off paper.

It has been speculated that FMO3 INDUCTION could be a potential therapy in that it may increase function by a few % (e.g. 10%, 20%). So if a harmless compound(s) could be found, it may be a potential therapy for 'text-book' FMO3 deficiency (not sure about those with TMAU2. Perhaps indirectly, but seems unlikely).

A current thought on this paper :
People in the TMAU community often complain of side-effects from potential 'FMO3 therapies'. FMO3 probably alters many compounds derived from plants. FMO3 has been part of living things probably from early evolution. A theory is that FMO3 was developed to dela with plant poisons (in the animal/plant evolution warfare). So with FMO3 deficiency it may be a case of the meat/poison saying.
So any lead in this area should probably be viewed with caution, perhaps expecting it to do more worse than good.

Wikipedia entry for FMO's 
"FMOs have gained a lot of attention in drug development since these enzymes are not readily induced or inhibited by the chemicals or drugs surrounding their environment.[14] CYPs are the primary enzymes involved in drug metabolism. However, recent efforts have been directed towards the development of drug candidates that incorporate functional groups that can be metabolized by FMOs. By doing this, the number of potential adverse drug-drug interactions is minimized and the reliance on CYP450 metabolism is decreased."

Cashman paper 2006 
 "In contrast to cytochrome P450 (CYP), FMO is not easily induced nor readily inhibited"

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Anonymous said...

Were in the USA can I purchase the herb

Dec 26, 2016, 5:47:00 PM
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