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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect

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Blog Archive

MEBO Research Clinical Trials

Click here to read details of the MEBO Clinical Trials
NCT03582826 - Ongoing not recruiting
Microbial Basis of Systemic Malodor and PATM Conditions (PATM)
United States 2018 - ongoing

NCT02683876 - Completed
Exploratory Study of Relationships Between Malodor and Urine Metabolomics
Canada and United States 2016 - ongoing

NCT03451994 - Completed
Exploratory Study of Volatile Organic Compounds in Alveolar Breath
United Kingdom and United States 2013 - ongoing

NCT02692495 - Completed
Evaluation of Potential Screening Tools for Metabolic Body Odor and Halitosis
United Kingdom 2009 - 2012

Tuesday, April 11, 2017

Metabolic Pathway Simulation: Apocrine Bromhidrosis compared to TMAU


Click for presentation

Danny Kunz has donated a very interesting PowerPoint presentation for the MEBO Conference 2017 consisting of metabolic pathway simulations on Apocrine Bromhidrosis compared to Trimethylaminuria. This presentation also discusses the role of the eccrine glands in bromhidrosis.

We are most grateful to Danny, who is a part of this, "loosely coupled group of patients (and non-patients) with academic degree and without academic degree integrating our separate research capabilities and representing an addressable unit."

This theory is supported by high throughput simulations backed by large enzyme databases, which makes it a very persuasive presentation. In other words, this group has done a computer simulation of bromhidrosis backed up by large enzyme databases, as Danny explains in the presentation. Their theory is that bromhidrosis is an apocrine and eccrine sweat glands metabolic disease.  Danny also says in his presentation that thyroid function with and without elevated hormone, TSH, may plays a role in bromhidrosis, and the group recommends supplementation and diet for this.

Even though the simulations discussed in this PowerPoint presentation do not have the aspect of medical proof yet, it provides a very compelling theory that calls for further research.

1.      Fecal (indole) breath and body odor and it's recommended supplementation and diet, 
2.      Apocrine and eccrine sweat glands metabolic disease in bromhidrosis,
a.      Discussions on isovaleric acid and amino acid leucine in eccrine bromhidrosis,
b.      Recommends a Thyroid functions blood test, with and without elevated Thyroid Stimulating Hormone (TSH), and recommended supplementation and diet.

This very interesting presentation raises question on whether TMAU2 to TMAU1 relation pattern could be transferred to the Bromhidrosis pattern as well.

Click for larger copy

We are most grateful to Danny Kunz and his colleagues for creating this very interesting presentation for our MEBO Annual Conference and Meetup 2017!


María de la Torre
Founder and Executive Director

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