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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info: https://youtu.be/811v7RLXP9M
MEBO Karen
at UK Findacure conf 2020

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MEBO TMAU TESTING DISCONTINUED
(2012-2017)

MEBO Map Testing & Meetups


Full details : https://goo.gl/TMw8xu
want listed ? contact info@meboresearch.org

MEBO - UBIOME study 2018

'PRESS RELEASE'

NCT03582826
ClinicalTrials.gov

MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production
& PATM

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person

NO LONGER RECRUITING

Participation info : LINK English

MEBO Private Facebook Group
to join : go to
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BO Sufferers Podcasts

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Petitions

TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study
NCT02683876

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned


Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
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EURORDIS and
NORD Member Organization
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MEBO survey for Dr Hazen click here
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Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

MEBO Research Clinical Trials

Sunday, December 22, 2019

$12 million NIH grant to Hazen lab for TMAO/microbiome research

$12 million grant from NIH.
Press release says first big grant from NIH into the gut microbiome.
to : Dr Hazen et al at Cleveland Clinic.
research : How TMAO and microbiome affects Cardiovascular Disease.
why ? : Hazen et al put forward a new hypothesis in 2011, that TMAO damages the cardiovascular system.

Dr Stanley Hazen et al at Cleveland Clinic got a new big grant from the NIH to continue their research into TMAO causing CVD
Cleveland Clinic press release Nov 2019

What has this to do with Metabolic Body Odor  ?
It will lead to more research into TMA metabolism in humans, and probably therapies to inhibit TMA generation in the gut. 
This grant is wider in context than TMAO only. It will look at the microbiome.

The program will consist of three specialized projects and four supporting cores. The projects will:
- explore how newly identified gut microbial pathways affect thrombosis and atherosclerosis
- investigate how microbial metabolites act like hormones to drive disease in a high-fat environment
- and identify specific microbial genes and metabolites that are responsible for enhancing cardiovascular disease.
The three projects will be led by Drs. Hazen and Brown, both of Cleveland Clinic’s Lerner Research Institute, and Dr. Michael Fischbach, of Stanford University. The four supporting cores will be led by Drs. Hazen, Brown, Wang and Hajjar, all from the Lerner Research Institute.

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1 comments:

Anonymous said...

Any news on the Procter & Gamble research?

Dec 26, 2019, 9:10:00 PM
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