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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
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MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

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Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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MEBO Metabolic Malodor Survey (international) for Dr Hazen click here
click to Read more/less

survey for ANYONE who identifies with METABOLIC MALODOR

begun : Oct20
end : no ending for now

Regular readers will know that Dr Stan Hazen et al at Cleveland Clinic are developing a TMA-blocker pill, as they proposed in a 2011 paper that TMAO is a factor in CVD. Recently Dr Hazen and colleagues contacted MEBO as they have always thought they could also help with TMAU. This survey is to give them an idea of the 'state of the community'. It is a "version 1". They may not even look (though they have access permission), but it could be useful to give them an overview of the community

MEBO had a zoom call with Dr Hazen and his team in October. Another zoom call is planned when they have time

This is a GOOGLE FORMS survey

short url for survey :

current participants : 113 (update 18dec20)

Tuesday, December 3, 2019

3 cases (2 'cured') of TMAU due to portosystemic shunt (Madrid)

Congenital Portosystemic Shunt (a 'liver shunt').
A bypass of the liver by the body's circulatory system.
Example : a vein forms between intestine artery and systemic artery.
Common in dogs and cats.
In humans ? (unknown). Is it regardless mostly harmless and not detected ?
Madrid Hospital, 2019.

A Madrid Hospital took a look at 15 cases of CPSS in humans. 
3 of them said they have TMAU.
After surgery to solve the CPSS (presumably cutting the rogue vein), 2 of them were pronounced 'cured' of TMAU.

How common might CPSS type TMAU be ?
Nobody knows.
Maybe little is known of CPSS in humans ?
One paper from a long time ago mentioned a baby with a Portal Shunt that's only problem was TMAU. Perhaps this inspired the researchers in this case.

It's another avenue for the TMAU community to discuss and explore, the concept of a Portal Shunt causing TMAU, which could be 'cured' (?) by surgery.   

Full paper : Link

This study aimed to report three new cases of an association between two rare conditions, congenital portosystemic shunts (CPSS) and trimethylaminuria (TMAU), and the efficacy of endovascular closure of the CPSS for resolving TMAU. Between November 2014 and April 2017, 15 patients with CPSS were enrolled in this prospective study to assess the efficacy of percutaneous endovascular shunt closure. Three patients presented with clinical symptoms of TMAU that were confirmed by urine analysis of trimethylamine (TMA) and TMA n-oxide. One year after endovascular closure of the congenital portosystemic shunt, the same parameters were evaluated were obtained and the values were compared to the pretreatment values. The results indicated the disappearance of clinical symptoms of TMAU and normalization of the urine test parameters in two patients and no changes in one patient, who developed new portosystemic communications.

General links :
Wikipedia PSS
Radiology : CPSS
Pubmed : 1 case in 1997

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Josh said...

Very interesting to see, that there can be different causes of TMAU2.

Dec 4, 2019, 2:29:00 AM
blogcontributor2 said...

I think the 'official' meaning of TMAU2 is 'anything that is not genetic TMAU (TMAU1)' ... but in practice is almost always due to TMA overload.

Dec 4, 2019, 4:54:00 AM
Anonymous said...

Im wondring if ammonia analyses would be a good thing to check before I go to a doctor duo this if ammonia way high too it could be a sign right ?

Dec 4, 2019, 11:16:00 AM
Anonymous said...

I had a gastric bypass in 1990 and subsequent reversal the next year due to complications. Years later After ending up with multiple injuries and c sections etc one after the other I was on narcotics for about 6 years. Not addicted just kept having issues and this constipated me to only go about once a week. I believe this is what (only tested properly after twenty years of excruciating time) prompted that bacteria overload that was stagnant for so long turned into prime feeding ground into tmau. Now I have been treated for SIBO, and still have the problem so that’s why I think it’s now tmau and here to stay. I smell very skunky in urine a feces.

Dec 4, 2019, 4:20:00 PM
Unknown said...

Im from canada please give some update about this and can my family doctor do that surgery for me here in canada...please let me know thank u..

Dec 18, 2019, 8:43:00 AM
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