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TMAU Petition world
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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Wednesday, February 10, 2021

TMAU Test in Italy : Messina

TMAU Test lab in MESSINA Italy

Medical Genetics Clinic
Pavilion F - Ground floor (Entrance F2)
Polyclinic “G. Martino ”of Messina
Via Consolare Valeria 1, Gazzi, Messina

Italy Messina TMAU test lab

Comment on the lab
It looks to be a University Genetics lab. Says 'Medical'. Possibly interested in TMAU mostly due to some research interest.  
They do seem to require any 'patient' to have a Dr referral.

Quotes from the site 

This site is managed by a group of researchers of the University of Messina who are involved in research, diagnosis, genetics and therapy of Trimethylaminuria ( TMAU ).

The operational core of our team consists of:

Prof.  Antonina SIDOTI , prof. associate of Biology and Genetics (BIO / 13) and head of the "Molecular Genetics" laboratory at the University of Messina, biologist executive of the "Medical Genetics" service of the Messina Polyclinic, deputy scientific director of the Euro Institute -Mediterraneo di Scienza e Tecnologia (IEMEST) of Palermo, of which he is also director of the department of “Biomolecular strategies, genetics and cutting-edge therapies”;

Dr.  Rosalia D'ANGELO , researcher at the “Molecular Genetics” laboratory of the University of Messina, biologist executive of the “Medical Genetics” service of the Messina Polyclinic Company;

Dr.  Carmela RINALDI , researcher at the "Molecular Genetics" laboratory of the University of Messina, biologist executive of the "Microbiology" service of the Messina Polyclinic Company;

Dr. Luigi DONATO , researcher at the Euro-Mediterranean Institute of Science and Technology (IEMEST) in Palermo, biologist and PhD in “Applied Biology and Experimental Medicine”; 

Dr.  Concetta SCIMONE , researcher at the Euro-Mediterranean Institute of Science and Technology (IEMEST) in Palermo, biotechnologist and PhD in “Biology and Cellular Biotechnology”, as well as specializing in “Medical Genetics”.

Dr.  Simona  ALIBRANDI , PhD Student in "Applied Biology and Experimental Medicine".

Prof.  Herbert Ryan MARINI , Aggregate Professor of Applied Dietetic Technical Sciences, SSD MED / 49, SC 06 / D2 - Endocrinology, Nephrology and Nutrition and Wellness Sciences, of the Department of Clinical and Experimental Medicine, at the University of Messina, and Equivalent Medical Director, UOC of Internal Medicine, DAI of Medical Sciences, AOU Policlinico “G. Martino ", Messina.

Prof.  Salvatore SETTINERI , associate professor of Clinical Psychology in the BIOMORF Department of the University of Messina.

Prof.  Maria Rosaria Anna MUSCATELLO , at the Clinical Psychology Unit of the Department of Biomedical, Dental and Morphological and Functional Imaging Sciences of the University of Messina, UOC of Psychiatry, AOU of G. Martino, Messina.


The diagnosis of TMAU is based on:

On the dosage of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) in the urine . This analysis is carried out after the administration of 5g of choline dissolved in orange juice or by administering a fish-based meal (300g). This determination makes it possible to distinguish carriers of the condition from unaffected individuals. It is based on the determination of the ratio of TMAO to TMA with normal reference values ​​≥0.90.

On the genetic test , based on the search for specific variants in the FMO3 gene related to a more or less severe impairment of the enzymatic function. The FMO3 gene maps to chromosome 1q23-q25 and is made up of nine exons. However, some people with TMAU may not have variants in this gene. For this reason it cannot be ruled out that variants in other genes may contribute to the onset of TMAU. 


We inform you that starting from January 2020, in order to carry out the pre-test genetic counseling, it is necessary to obtain the prescription from the attending physician bearing the following wording "General visit code 897" and to book at the numbers of the CUP (Single Booking Center)  0902213976 or 0902213977 , from Monday to Friday , specifying that the genetic counseling will be conducted by Dr. Silvana Briuglia . 

Since genetic testing is not provided for the secondary form of TMAU, it is advisable to contact our working group through our contacts , before proceeding with the booking through CUP, in order to evaluate together if the conditions for the prescription of the genetic test.

We also inform you that for the prescription of the genetic test it is also possible to contact a medical geneticist in your region. In this case, for more information regarding the forms and sending the blood sample, you can contact our contacts.


For more information contact us at the following email address:

Or at the following telephone number (Italy) :


Email update from Messina Lab

Our lab performs the TMAU genetic test even for patients who do not live in Italy. The test is free because it is carried out with research fund money contributions, especially for patients who cannot pay or for any other reasons. Therefore we cannot release an official report, but we will be able to let you know if you have TMAU or not, in a mild o severe form

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