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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

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MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Blog Archive

Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Saturday, April 13, 2024

Unveiling the Breath: Propylene Oxide as a Diagnostic Marker

In the past 15 years, MEBO Research has been at the forefront of unraveling the mysteries behind TMAU and related undiagnosed conditions not yet accepted by medical establishment. Our journey began with blood tests and challenge tests like the choline and glucose challenge, aimed at understanding gut fermentation profiles. Over time, we discovered the link between various types of MEBO and PATM and the microbiome. 
While malodorous skin bacteria in the gut were a common factor, we also uncovered many variations and subtle imbalances contributing to TMAU-like or PATM perception.

Our ultimate goal was to avoid challenge tests, leading us to also explore urine metabolomics. Collaborating with Dr. Wishart, we found that while challenging, it's possible to detect malodor signatures in fasting morning urine. However, the influence of diet posed a significant challenge, resulting in numerous subtypes.

In 2012-2013, in collaboration with Dr. Phillips and Menssana Research, we started the Breath Metabolomics study. We hypothesized that fasting morning breath metabolites would hold signatures for conditions like Trimethylaminuria (TMAU) and TMAU-like conditions such as PATM. Our findings revealed significant differences, particularly in the detoxification of environmental compounds.

Our new paper posted on MedRxiv reports some of the results from the Breath Metabolomics study, emphasizing compounds associated with oxidative stress and environmental toxins like Propylene Oxide. These compounds have proven effective in distinguishing individuals who have never tested positive for TMAU from those who have. Could this mark a turning point in our efforts to comprehend and tackle undiagnosed malodor conditions?

PAPER: Irene S. Gabashvili 2024 Propylene Oxide in Exhaled Breath as a Marker for Discriminating TMAU-like Conditions from TMAU medRxiv 2024.04.11.24305677; doi:

Clinical Trial: NCT03451994


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