Unveiling the Breath: Propylene Oxide as a Diagnostic Marker

In the past 15 years, MEBO Research has been at the forefront of unraveling the mysteries behind TMAU and related undiagnosed conditions not yet accepted by medical establishment. Our journey began with blood tests and challenge tests like the choline and glucose challenge, aimed at understanding gut fermentation profiles. Over time, we discovered the link between various types of MEBO and PATM and the microbiome. 

While malodorous skin bacteria in the gut were a common factor, we also uncovered many variations and subtle imbalances contributing to TMAU-like or PATM perception.

Our ultimate goal was to avoid challenge tests, leading us to also explore urine metabolomics. Collaborating with Dr. Wishart, we found that while challenging, it's possible to detect malodor signatures in fasting morning urine breath. However, the influence of diet posed a significant challenge, resulting in numerous subtypes.

In 2012-2013, in collaboration with Dr. Phillips and Menssana Research, we started the Breath Metabolomics study. We hypothesized that breath metabolites would hold signatures for conditions like Trimethylaminuria (TMAU) and TMAU-like conditions such as PATM. Our findings revealed significant differences, particularly in the detoxification of environmental compounds.

Our new paper posted on MedRxiv reports some of the results from the Breath Metabolomics study, emphasizing compounds associated with oxidative stress and environmental toxins like Propylene Oxide. These compounds have proven effective in distinguishing individuals who have never tested positive for TMAU from those who have. Could this mark a turning point in our efforts to comprehend and tackle undiagnosed malodor conditions?

PAPER: Irene S. Gabashvili 2024 Propylene Oxide in Exhaled Breath as a Marker for Discriminating TMAU-like Conditions from TMAU medRxiv 2024.04.11.24305677; doi: https://doi.org/10.1101/2024.04.11.24305677

DATA: OSF | Biological Factors that Influence Individual Responses to Environmental Epoxides

Clinical Trial: NCT03451994

 

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