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March20 podcast Dr Hazen
anti-TMA pill in a year or 2 ? (scroll 12 mins)

Additional info:
MEBO Karen
at UK Findacure conf 2020

Scroll down and select country

MEBO Map Testing & Meetups

Full details :
want listed ? contact

MEBO - UBIOME study 2018



MEBO Gut Microbiome Study
"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"
Funded by uBiome Research Grant

"Microbial Basis of Systemic Malodor and PATM Conditions (PATM)"

Dynamics of the Gut Microbiota in
Idiopathic Malodor Production

Started May 2018 - Ongoing

Current people sent kits : 100/100
3 kits per person


Participation info : LINK English

MEBO Private Facebook Group
to join : go to
or contact
Join/Watch the weekly
BO Sufferers Podcasts



TMAU Petition world
TMAU UK end total:262
TMAU UK ends 23/01/20
TMAU Petition USA end total 204
USA : Moveon open
TMAU (Dominican)
Metabolomic Profiling Study

Start : Aug 2016
Stage 1 : 27 Canadian volunteers to test
Latest click here (26 oct) :
17 samples returned

Note : Stage 1 is Canada only.
Return cut-off date : passed
Analysis can take 6/8 weeks
Analysis start in/before Nov
MEBO Research is a
NORD Member Organization
See RareConnect TMAU

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Denver TMAU Test Lab survey click here
click to Read more/less

USA survey for anyone who wants to improve Denver TMAU test

begun : Dec22
end : no ending for now

A trainee genetic counselor is working at the Denver TMAU test lab. Probably as part of her training. As a project she wishes feedback on any aspect of the Denver TMAU test and process. You can fill in the survey and/or email her (email address is in survey). It's meant for USA people, but perhaps others can give their view too (as we have so few opportunities).

quote from her rareconnect post

"Hello all! I wanted to make you aware of a research study being conducted to better understand the experience and needs of individuals with trimethylaminuria with a goal of being able to create improved patient and healthcare provider education materials. Any participation is completely voluntary and all responses remain confidential. Feel free to use the contact information within the link with any questions or share the survey with others with TMAU."

see this post for more details

Saturday, June 8, 2024

message from FSU IGEM 2024 team (re TMA Breathalyzer)

About iGEM and it's annual competition (this year Oct24)
The iGEM Competition is an annual, worldwide synthetic biology event aimed at undergraduate university students, as well as high school and graduate students. The iGEM Competition gives students
Click to expand for more details the opportunity to push the boundaries of synthetic biology by tackling everyday issues facing the world. Multidisciplinary teams work together to design, build, test, and measure a system of their own design using interchangeable biological parts and standard molecular biology techniques.

The Florida State University 2023 team took an interest in solutions for Trimethylaminuria.
They developed a 'probiotic' that metabolizes Trimethylamine (TMA) in the gut.
As far as we know they got a small grant from FSU to continue after the 2023 iGEM competition.

FSU iGEM team 2024 project : a TMA Breathalyzer.
A TMA sensor is very much needed as most sufferers are anosmic to their smells.
It also seems that often close relatives and other 'loved' ones may be anosmic too (1 theory being they are genetic mix carriers, not enough to be sufferers). 
It's unknown why this is (seems to be true for all types of BO or Halitosis ?).
Theories are like e.g. you get used to it (like lillies), or the brain ignores blood odors.

The 'health' research system has had little interest in TMAU.
Once you understand the system, its a bit surprising any therapy is discovered (at least, within decades).
The covid vaccine showed what was possible when the system focus was sensible. 
Normally that would have taken a decade or 2.

Message from FSU iGEM Team
We are pleased to post a message from the 2024 FSU iGEM team.
Thank you FSU iGEM 2023 and 2024 for your interest in TMAU.
The anti-TMA probiotic concept and a TMA Breathalyzer is as good a combo we could wish for (in terms of a current realistic working therapy). 
Hello MEBO Community,  

Our names are Megan Perusse and Lucas Bonassi, we are third year undergraduate students at Florida State University, and we are the co-leads for the 2024 FSU iGEM team. We just wanted to reach out and update the community on the 2024 project.  

Each year, the iGEM team consists of new members, and those new members select a new project topic to focus on. The 2024 team was moved by the struggles of the TMAU patient community and inspired by the potential impact of the 2023 team, so we chose to continue
 focusing on TMAU for this year’s project. However, we are not continuing to work on the probiotic that was developed by the 2023 team. Further research on the probiotic has been taken up by the FSU Institute for Pediatric Rare Diseases, so we unfortunately
 do not have up to date information regarding the progress of that project. Along with the work being done by the Institute, some current and past members of our 2024 and 2023 teams are working to create a start-up to focus on the potential commercialization
 and further development of the therapeutic and later diagnostic. 
Instead, the 2024 team is focusing on developing a breathalyzer device to measure TMA levels. This would theoretically be used along with the probiotic to measure how much TMA the body is producing and therefore how much of the probiotic to use. Our hope is
 that this will allow those of you in the community to gain more freedom in your lives and allow you to manage your symptoms around your life, rather than your life around your symptoms. 

Our engineering team has a design and are currently ordering the supplies needed to begin testing in the lab over the next few months. We will make sure to post another update regarding our progress before the end of the competition in October. At that time,
 we will share with you our project website and video presentation as well.  

Thank you for your continued support, and we are working hard to help the TMAU community!

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