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Saturday, January 31, 2009

Some extracts on FMO enzymes in books via googlebooks

The Flavin Mono-oxygenase 3 enzyme is said to be flawed in a diagnosis of Primary Trimethylaminuria (despite anecdotal test results of DNA suggesting otherwise, and also a dissertation where 8/12 had no mutants/variants). The enzyme deals with a lot of odorous substrates; sulfides and amines and phosphorus compounds. As textbooks currently say, since these other compounds are thought to be able to go a slower complex alternative route, via the P450 enzymes, (P450 and FMO are regarded as a layer of oxidizing activating/detoxing enzymes - the phase 1 enzymes) the other sulfides and amines aren't regarded as un-oxidizable as trimethylamine is. Perhaps this enzyme will turn out to be the main 'smelly' enzyme and perhaps the problem is to do with a backlog of these substrates. Trimethylamine doesn't seem to explain fecal body odor, whereas other sulfides and amines seem plausible.

For this reason, it is probabably useful to know about these enzymes, and in particular, FMO3. This is a good extract from a 2003 Molecular Toxicology book about the FMO family of enzymes.

Molecular Toxicology By Nick Plant: FMO

This chapter is from a 'gold standard' 2001 medical book on toxicology, the chapter dealing with the xenobiotic metabolizing enzymes (aka drug metabolizing enzymes, first pass enzymes, phase1/phase2 enzymes).

Casarett and Doull's Toxicology: Biotransformation of xenobiotics

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