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Monday, April 13, 2009

genetically engineered bacteria : one possible treatment for TMAU

It has been hypothesized a decade or so ago by a researcher interested in FMO3 at the time (the late 90s were the heyday of FMO3 research amongst those few world scientists with an interest in subject), that one possible treatment could be genetically engineered bacteria that was enriched with FMO3 enzyme and could colonize the gut (presumably the colon). It could then detoxify the trimethylamine produced in-situ. This technology has probably been possible 10 or 15 years, and the main reasons it hasn't happened is likely that any scientist who has a history of FMO3 research is doing whatever they do (the last 2 'new research' TMAU papers over the last 2 years were possibly part of a researchers qualification papers, with the subject not to be returned to), and there is no orders from governments to do so.

This video demonstrates the principle. Rob Brown of the Australian TMAU support group has spoken of such research possibly happening in Australia, and it has been mentioned in the blog before. It would be a pity if it hasn't become a reality already, perhaps years ago, purely because it is thought there is no great need in society for such research.

This second video made by schoolkids for a project explains how the human insulin gene is genetically engineered into bacteria for diabetes. This seems to have had FDA approval since 1982. The only difference for TMAU would likely be that the patient would eat the bacteria, as a probiotic.


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